Pairing SOX off with partners in the regulation of embryonic development

被引：528

作者：

Kamachi, Y ^{[1
]}

Uchikawa, M ^{[1
]}

Kondoh, H ^{[1
]}

机构：

[1] Osaka Univ, Inst Mol & Cellular Biol, Suita, Osaka 5650871, Japan

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(99)01955-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The SOX family of high-mobility group (HMG) domain proteins has recently been recognized as a key player in the regulation of embryonic development and in the determination of the cell fate. In the case of certain SOX proteins, they regulate the target genes by being paired off with specific partner factors. This partnering: might allow SOX proteins to act in a cell-specific manner, which is key to their role in cell differentiation. The focus of this article is the mechanism of action of SOX proteins, in particular, how SOX proteins specifically pair off with respective partner factors and, as a consequence, select distinct sets of genes as their regulatory targets.

引用

页码：182 / 187

页数：6

共 32 条

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