Separation and sensitive detection of D-amino acids in biological matrices

被引：54

作者：

Kirschner, Daniel L. ^{[1
]}

Green, Thomas K.

机构：

[1] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA

来源：

JOURNAL OF SEPARATION SCIENCE | 2009年 / 32卷 / 13期

关键词：

CD; D-Amino acid; D-Aspartate; D-Serine; Enantioseparation; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PERFORMANCE LIQUID-CHROMATOGRAPHY; INDUCED FLUORESCENCE DETECTION; CENTRAL-NERVOUS-SYSTEM; D-ASPARTIC ACID; MICRODIALYSIS-CAPILLARY ELECTROPHORESIS; AQUEOUS-ORGANIC MEDIA; FREE D-ALANINE; D-SERINE; RAT-BRAIN;

D O I：

10.1002/jssc.200900101

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The increase in our understanding of D-amino acid function and distribution in mammals is in many ways a result of the initial development of sensitive enantioselective separation strategies that allow for quantification in real biological samples. This article reviews progress on the development of chiral selective separation and detection Of D-amino acids including enzyme-based microbiosensors, GC/MS, HPLC/fluorescence, HPLC/MS-MS, cEKC/fluorescence, and MEKC/fluorescence. Only methods capable of analyzing D-isomers in biological matrices are given here and significant effort is made to highlight approaches that offer speed, resolution, high sensitivity, and versatility.

引用

页码：2305 / 2318

页数：14

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