Ghrelin

被引：841

作者：

Mueller, T. D. ^{[1
]}

Nogueiras, R. ^{[2
]}

Andermann, M. L. ^{[3
]}

Andrews, Z. B. ^{[4
]}

Anker, S. D. ^{[5
]}

Argente, J. ^{[6
,7
,8
]}

Batterham, R. L. ^{[9
]}

Benoit, S. C. ^{[10
]}

Bowers, C. Y. ^{[11
]}

Broglio, F. ^{[12
]}

Casanueva, F. F. ^{[13
]}

D'Alessio, D. ^{[14
]}

Depoortere, I. ^{[15
]}

Geliebter, A. ^{[16
]}

Ghigo, E. ^{[17
]}

Cole, P. A. ^{[18
]}

Cowley, M. ^{[4
,18
]}

Cummings, D. E. ^{[19
]}

Dagher, A. ^{[20
]}

Diano, S. ^{[21
]}

Dickson, S. L. ^{[22
]}

Dieguez, C. ^{[23
]}

Granata, R. ^{[12
]}

Grill, H. J. ^{[24
]}

Grove, K. ^{[25
]}

Habegger, K. M. ^{[26
]}

Heppner, K. ^{[27
]}

Heiman, M. L. ^{[28
]}

Holsen, L. ^{[29
,30
,31
]}

Holst, B. ^{[32
]}

Inui, A. ^{[33
]}

Jansson, J. O. ^{[34
]}

Kirchner, H. ^{[35
]}

Korbonits, M. ^{[36
]}

Laferrere, B. ^{[37
]}

LeRoux, C. W. ^{[38
]}

Lopez, M. ^{[2
]}

Morin, S. ^{[1
]}

Nakazato, M. ^{[39
]}

Nass, R. ^{[40
]}

Perez-Tilve, D. ^{[41
]}

Pfluger, P. T. ^{[1
]}

Schwartz, T. W. ^{[42
]}

Seeley, R. J. ^{[43
]}

Sleeman, M. ^{[4
]}

Sun, Y. ^{[44
]}

Sussel, L. ^{[45
]}

Tong, J. ^{[14
]}

Thorner, M. O. ^{[40
]}

van der Lely, A. J. ^{[46
]}

机构：

[1] Helmholtz Zentrum Munchen, Inst Diabet & Obes, Munich, Germany

[2] Univ Santiago de Compostela CIMUS, Ctr Investc Med Mol & Enfermedades Cron, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Inst Invest Sanitaria IDIS,Dept Physiol, Santiago De Compostela, Spain

[3] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol, Boston, MA 02215 USA

[4] Monash Univ, Dept Physiol, Fac Med, Melbourne, Vic 3168, Australia

[5] Charite Univ Med Berlin, Dept Cardiol, Appl Cachexia Res, Berlin, Germany

[6] Hosp Infantil Univ Nino Jesus, Inst Invest La Princesa, Dept Pediat & Pediat Endocrinol, Madrid, Spain

[7] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain

[8] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain

[9] UCL, Ctr Obes Res, London, England

[10] Univ Cincinnati, Coll Med, Dept Med, Div Endocrinol,Metab Dis Inst, Cincinnati, OH USA

[11] Tulane Univ, Hlth Sci Ctr, Endocrinol & Metab Sect, Peptide Res Sect, New Orleans, LA 70118 USA

[12] Univ Turin, Dept Med Sci, Div Endocrinol Diabet & Metab, Turin, Italy

[13] Univ Santiago de Compostela, CHUS, CIBER Fisiopatol Obesidad & Nutr CB06 03, Inst Salud Carlos III,Dept Med, Santiago De Compostela, Spain

[14] Duke Univ, Duke Mol Physiol Inst, Durham, NC USA

[15] Univ Leuven, Translat Res Ctr Gastrointestinal Disorders, Leuven, Belgium

[16] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Dept Med, New York Obes Nutr Res Ctr, New York, NY 10032 USA

[17] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[18] Monash Univ, Monash Obes & Diabet Inst, Clayton, Vic, Australia

[19] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Sch Med, Seattle, WA 98195 USA

[20] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[21] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT USA

[22] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol Endocrinol, Gothenburg, Sweden

[23] Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Sch Med, Dept Physiol, Santiago De Compostela, Spain

[24] Univ Penn, Dept Psychol, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

[25] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Dept Diabet Obes & Metab, Beaverton, OR 97006 USA

[26] Univ Alabama Birmingham, Sch Med, Comprehens Diabet Ctr, Birmingham, AL USA

[27] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR 97006 USA

[28] NuMe Hlth, New Orleans, LA 70112 USA

[29] Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA

[30] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[31] Harvard Univ, Sch Med, Boston, MA USA

[32] Univ Copenhagen, Dept Neurosci & Pharmacol, Copenhagen N, Denmark

[33] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Kagoshima 890, Japan

[34] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden

[35] Univ Klinikum Schleswig Holstein, Med Klin 1, D-23538 Lubeck, Germany

[36] Queen Mary Univ London, William Harvey Res Inst, Ctr Endocrinol, London, England

[37] Columbia Univ Coll Phys & Surg, Dept Med, New York Obes Res Ctr, New York, NY 10032 USA

[38] Univ Coll Dublin, Conway Inst, Diabet Complicat Res Ctr, Dublin, Ireland

[39] Miyazaki Univ, Fac Med, Dept Internal Med, Div Neurol Respirol Endocrinol & Metab, Miyazaki, Japan

[40] Univ Virginia, Div Endocrinol & Metab, Charlottesville, VA USA

[41] Univ Cincinnati, Coll Med, Dept Med, Dept Internal Med, Cincinnati, OH USA

[42] Univ Copenhagen, Panum Inst, Mol Pharmacol Lab, Dept Neurosci & Pharmacol, DK-2200 Copenhagen, Denmark

[43] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI USA

[44] Baylor Coll Med, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA

[45] Columbia Univ, Dept Genet & Dev, New York, NY USA

[46] Erasmus Univ MC, Dept Med, Rotterdam, Netherlands

[47] Rhythm Pharmaceut, Boston, MA USA

[48] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[49] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[50] Kurume Univ, Inst Life Sci, Mol Genet, Kurume, Fukuoka 830, Japan

来源：

MOLECULAR METABOLISM | 2015年 / 4卷 / 06期

关键词：

Ghrelin; Growth hormone segretagogue receptor; GROWTH-HORMONE SECRETAGOGUE; DES-ACYL GHRELIN; O-ACYLTRANSFERASE GOAT; HIGH-FAT-DIET; BROWN ADIPOSE-TISSUE; BODY-MASS INDEX; LAPAROSCOPIC SLEEVE GASTRECTOMY; STIMULATES LOCOMOTOR-ACTIVITY; BETA-ADRENERGIC-RECEPTORS; INCREASES FOOD-INTAKE;

D O I：

10.1016/j.molmet.2015.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism. (C) 2015 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：437 / 460

页数：24

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