Choosing statins: a review to guide clinical practice

被引：12

作者：

Borges, Roberta de Padua ^{[1
]}

Habib Degobi, Nathalia Abi ^{[3
]}

Bertoluci, Marcello Casaccia ^{[2
,3
,4
]}

机构：

[1] Univ Fed Rio Grande do Sul UFRGS, Programa Posgrad Endocrinol, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul UFRGS, Programa Posgrad Ciencias Med, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul UFRGS, Serv Endocrinol, Hosp Clln Porto Alegre HCPA, Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul UFRGS, Dept Med Interna, Fac Med, Porto Alegre, RS, Brazil

来源：

ARCHIVES OF ENDOCRINOLOGY METABOLISM | 2020年 / 64卷 / 06期

关键词：

Statins; cardiovascular disease; cholesterol; type; 2; diabetes; LOWERING LDL CHOLESTEROL; RENAL-TRANSPLANT RECIPIENTS; CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR-DISEASE; EJECTION FRACTION; DRUG-INTERACTIONS; GLYCEMIC CONTROL; ELDERLY-PATIENTS; HIV-INFECTION;

D O I：

10.20945/2359-3997000000306

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment.This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions.Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios.

引用

页码：639 / 653

页数：15

共 89 条

[1]

Aberg JA, 2017, LANCET HIV, V4, pE283

[2] Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis [J].

Abraldes, Juan G. ;

Villanueva, Candid ;

Aracil, Carles ;

Turnes, Juan ;

Hernandez-Guerra, Manuel ;

Genesca, Joan ;

Rodriguez, Manuel ;

Castellote, Jose ;

Carlos Garcia-Pagan, Juan ;

Torres, Ferran ;

Luis Calleja, Jose ;

Albillos, Agustin ;

Bosch, Jaime .

GASTROENTEROLOGY, 2016, 150 (05) :1160-+

[3] Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial [J].

Abraldes, Juan G. ;

Albillos, Agustin ;

Banares, Rafael ;

Turnes, Juan ;

Gonzalez, Rosario ;

Garcia-Pagan, Juan Carlos ;

Bosch, Jaime .

GASTROENTEROLOGY, 2009, 136 (05) :1651-1658

[4] Effectiveness of drug interventions to prevent sudden cardiac death in patients with heart failure and reduced ejection fraction: an overview of systematic reviews [J].

Al-Gobari, Muaamar ;

Al-Aqeel, Sinaa ;

Gueyffier, Francois ;

Burnand, Bernard .

BMJ OPEN, 2018, 8 (07)

[5] No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials [J].

Al-Gobari, Muaamar ;

Le, Hai-Ha ;

Fall, Mor ;

Gueyffier, Francois ;

Burnand, Bernard .

PLOS ONE, 2017, 12 (02)

[6] Association Between Use of Statins and Mortality in Patients With Heart Failure and Ejection Fraction of ≥50% [J].

Alehagen, Urban ;

Benson, Lina ;

Edner, Magnus ;

Dahlstrom, Ulf ;

Lund, Lars H. .

CIRCULATION-HEART FAILURE, 2015, 8 (05) :862-870

[7]

Amarenco P, 2006, NEW ENGL J MED, V355, P549

[8] Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM) [J].

Bertoluci, Marcello Casaccia ;

Moreira, Rodrigo Oliveira ;

Faludi, Andre ;

Izar, Maria Cristina ;

Schaan, Beatriz D. ;

Valerio, Cynthia Melissa ;

Bertolami, Marcelo Chiara ;

Chacra, Ana Paula ;

Bolivar Malachias, Marcus Vinicius ;

Vencio, Sergio ;

Kerr Saraiva, Jose Francisco ;

Betti, Roberto ;

Turatti, Luiz ;

Helfenstein Fonseca, Francisco Antonio ;

Bianco, Henrique Tria ;

Sulzbach, Marta ;

Bertolami, Adriana ;

Nunes Salles, Joao Eduardo ;

Hohl, Alexandre ;

Trujilho, Fabio ;

Lima, Eduardo Gomes ;

Miname, Marcio Hiroshi ;

Zanella, Maria Teresa ;

Lamounier, Rodrigo ;

Sa, Joao Roberto ;

Amodeo, Celso ;

Pires, Antonio Carlos ;

Santos, Raul D. .

DIABETOLOGY & METABOLIC SYNDROME, 2017, 9

[9]

[Anonymous], 2009, JAMA J AM MED ASSOC

[10] Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis [J].

Athyros, Vasilios G. ;

Tziomalos, Konstantinos ;

Gossios, Thomas D. ;

Griva, Theodora ;

Anagnostis, Panagiotis ;

Kargiotis, Konstantinos ;

Pagourelias, Efstathios D. ;

Theocharidou, Eleni ;

Karagiannis, Asterios ;

Mikhailidis, Dimitri P. .

LANCET, 2010, 376 (9756) :1916-1922

← 1 2 3 4 5 6 7 8 9 →