Salivary duct carcinoma:: cytokeratin 14 as a marker of in-situ intraductal growth

被引：10
作者：
de Araújo, VC
Loducca, SVL
Sobral, APV
Kowalski, LP
Soares, F
de Araújo, NS
机构：
[1] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, BR-05508900 Sao Paulo, Brazil
[2] Univ Estadual Pernambuco, Dept Oral Pathol, Sch Dent, Sao Paulo, Brazil
[3] Canc Hosp AC Camargo, Sao Paulo, Brazil
来源：
HISTOPATHOLOGY | 2002年 / 41卷 / 03期
关键词：
salivary duct carcinoma; immunohistochemistry; cytokeratins;
D O I：
10.1046/j.1365-2559.2002.01454.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aims:The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth. Methods and results: We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and alpha-smooth muscle actin) in five cases of salivary duct carcinoma. This panel is currently used for identification of different components of salivary gland tumours in our laboratory. All tumour cells were positive for cytokeratins 7 and 8. Few neoplastic structures expressed cytokeratin 14 in cells surrounding tumour islands. Conclusion: The finding of cytokeratin 14 was important to confirm the in-situ intraductal growth, which probably characterizes this low-grade neoplasm.
引用
收藏
页码：244 / 249
页数：6
相关论文
共 28 条
[1]  
ANDERSON C, 1992, CANCER, V69, P609, DOI 10.1002/1097-0142(19920201)69:3<609::AID-CNCR2820690302>3.0.CO
[2]  
2-1
[3]  
ARAUJO V C D, 1987, Oral Surgery Oral Medicine Oral Pathology, V63, P592
[4]  
ARAUJO VC, 1996, ORAL ONCOL, V32, P14
[5]  
ARAUJO VC, 2000, APPL IMMUNOHISTO M M, V8, P195
[6]   SALIVARY DUCT CARCINOMA .2. IMMUNOHISTOCHEMICAL EVALUATION OF 13 CASES FOR ESTROGEN AND PROGESTERONE RECEPTORS, CATHEPSIN-D, AND C-ERB-2 PROTEIN [J].
BARNES, L ;
RAO, U ;
CONTIS, L ;
KRAUSE, J ;
SCHWARTZ, A ;
SCALAMOGNA, P .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1994, 78 (01) :74-80
[7]   SALIVARY DUCT CARCINOMA .1. A CLINICOPATHOLOGICAL EVALUATION AND DNA IMAGE-ANALYSIS OF 13 CASES WITH REVIEW OF THE LITERATURE [J].
BARNES, L ;
RAO, U ;
KRAUSE, J ;
CONTIS, L ;
SCHWARTZ, A ;
SCALAMOGNA, P .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1994, 78 (01) :64-73
[8]  
BATSAKIS JG, 1994, ADV ANAT PATHOL, V1, P29
[9]  
BRANDWEIN MS, 1990, CANCER, V65, P2307, DOI 10.1002/1097-0142(19900515)65:10<2307::AID-CNCR2820651024>3.0.CO
[10]  
2-1
123