Haploidentical stem cell transplantation for the treatment of leukemia: current status

被引：17

作者：

Chang, Ying-Jun ^{[1
,2
]}

Wang, Yu ^{[1
,2
]}

Huang, Xiao-Jun ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China

[2] Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

[3] Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

来源：

EXPERT REVIEW OF HEMATOLOGY | 2014年 / 7卷 / 05期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

graft-versus-leukemia effects; haploidentical stem cell transplantation; leukemia; relapse; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; UMBILICAL-CORD BLOOD; RISK ACUTE-LEUKEMIA; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD; DONOR LYMPHOCYTE INFUSIONS; HEMATOLOGIC MALIGNANCIES; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE;

D O I：

10.1586/17474086.2014.954543

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Haploidentical stem cell transplantation (haplo-SCT), either with T-cell depletion or T-cell replete, has been a reliable source of stem cells for patients with high-risk leukemia who do not have matched donors because it provides comparable outcomes to human leukocyte antigen-matched sibling donor transplantation, unrelated donor transplantation and umbilical cord blood transplantation. Factors, such as the Hematopoietic Cell Transplantation-Specific Comorbidity Index, associated with transplant outcomes may help us design risk-stratification-directed intervention to improve the prognosis of leukemia patients. Preliminary results of novel protocols, including co-transplant of haploidentical allografts and cord blood, as well as human leukocyte antigen-mismatched stem cell microtransplantation, for leukemia have shown that these approaches are feasible. Several strategies for enhancing the graft-versus-leukemia effects significantly decreased the relapse rate after haplo-SCT. Future direction of research will focus on perfecting available haplo-SCT protocols and determining the optimal time of haplo-SCT for leukemia and 'fit' haploidentical transplant candidates.

引用

页码：635 / 647

页数：13

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