Smac combined with DDP can inhibit drug resistance of ovarian cancer through regulation of Survivin expression

被引：7
作者：
Chen, Qi [1 ]
Zhang, Hong [1 ]
机构：
[1] Tianjin Cent Hosp Gynecol & Obstet, Dept Gynecol Oncol, Tianjin 300100, Peoples R China
来源：
CANCER BIOMARKERS | 2018年 / 22卷 / 01期
关键词：
Smac; DDP; drug-resistant; ovarian cancer cell; Survivin; TARGETING SURVIVIN; BLADDER-CANCER; CELLS; APOPTOSIS; SMAC/DIABLO; CISPLATIN; GROWTH; CHEMOSENSITIVITY; AUGMENTS; SIRNA;
D O I：
10.3233/CBM-170325
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer has the highest mortality rate among gynecological malignancies, presenting a major threat to women's life and health. It is essential to study the mechanisms of drug resistance to chemotherapy to identify ways to enhance drug-sensitivity. In recent years, many studies have shown that Smac/DIABLO is closely related to tumor drug resistance. Smac/DIABLO expression is markedly different between drug-resistant and chemo sensitive tumor cells. Up-regulation of Smac/DIABLO has been shown to increase tumor cell chemotherapy sensitivity. We found that Smac, combined with DDP greatly inhibited proliferation of subcutaneous xenografts of ovarian cancer cell line SKOV3/DDP without side effects. Mechanistic studies showed that Smac can inhibit the expression of Survivin, promote cell apoptosis of drug-resistant ovarian cancer cells and reverse the drug resistance.
引用
收藏
页码：1 / 6
页数：6
相关论文
共 50 条
  • [21] Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors
    Basha, Riyaz
    Ingersoll, Susan B.
    Sankpal, Umesh T.
    Ahmad, Sarfraz
    Baker, Cheryl H.
    Edwards, John R.
    Holloway, Robert W.
    Kaja, Sumanth
    Abdelrahim, Maen
    GYNECOLOGIC ONCOLOGY, 2011, 122 (01) : 163 - 170
  • [22] Expression of KAP1 in epithelial ovarian cancer and its correlation with drug-resistance
    Hu, Mingqiu
    Fu, Xin
    Cui, Yanfen
    Xu, Shilei
    Xu, Yue
    Dong, Qiuping
    Sun, Lu
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (10): : 17308 - 17320
  • [23] Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance
    Gao, Jian
    Hu, Zhenhua
    Liu, Juanjuan
    Liu, Dawo
    Wang, Yanyan
    Cai, Mingbo
    Zhang, Danye
    Tan, Mingzi
    Lin, Bei
    MEDICAL ONCOLOGY, 2014, 31 (05)
  • [24] MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis
    Mak, Celia S. L.
    Yung, Mingo M. H.
    Hui, Lynn M. N.
    Leung, Leanne L.
    Liang, Rui
    Chen, Kangmei
    Liu, Stephanie S.
    Qin, Yiming
    Leung, Thomas H. Y.
    Lee, Kai-Fai
    Chan, Karen K. L.
    Ngan, Hextan Y. S.
    Chan, David W.
    MOLECULAR CANCER, 2017, 16
  • [25] Low-dose radiation reverses cisplatin resistance in ovarian cancer cells by changing Survivin and Caspase-3 expression
    Qing Dong
    Tao Jiang
    Donghai Liang
    Xiaoran Liu
    Hongsheng Yu
    Oncology and Translational Medicine, 2016, 2 (02) : 90 - 95
  • [26] Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer
    Gao, Yan
    Foster, Rosemary
    Yang, Xiaoqian
    Feng, Yong
    Shen, Jacson K.
    Mankin, Henry J.
    Hornicek, Francis J.
    Amiji, Mansoor M.
    Duan, Zhenfeng
    ONCOTARGET, 2015, 6 (11) : 9313 - 9326
  • [27] Xanthatin induce DDP-resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation
    Liu, Yunxiao
    Zhang, Xinge
    Cheng, Fenting
    Cao, Wei
    Geng, Yadi
    Chen, Zhaolin
    Wei, Wei
    Zhang, Lei
    DRUG DEVELOPMENT RESEARCH, 2023, 84 (06) : 1266 - 1278
  • [28] Study on Cantharidin Reversing the Drug-resistance of Nonsmall Cell Lung Cancer to DDP by Regulating the Expression of PD-L1
    Jin, Xing
    Ma, Chunhui
    Tan, Xiaojing
    Qian, Jian
    Chen, Yongbing
    Wang, Dongfeng
    PHARMACOGNOSY MAGAZINE, 2025, 21 (01) : 74 - 80
  • [29] Inhibition of Beclin 1 Expression Enhances Cisplatin-Induced Apoptosis Through a Mitochondrial-Dependent Pathway in Human Ovarian Cancer SKOV3/DDP Cells
    Sun, Yang
    Liu, Jia-hua
    Jin, Long
    Sui, Yu-xia
    Lai, Li
    Yang, Yin
    ONCOLOGY RESEARCH, 2013, 21 (05) : 261 - 269
  • [30] Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of survivin expression
    Bhattacharyya, Joyeeta
    Mihara, Keichiro
    Ohtsubo, Motoaki
    Yasunaga, Shin'ichiro
    Takei, Yoshifumi
    Yanagihara, Kazuyoshi
    Sakai, Akira
    Hoshi, Masaharu
    Takihara, Yoshihiro
    Kimura, Akiro
    CANCER SCIENCE, 2012, 103 (01): : 34 - 41
12345