Exosomes: A New Weapon to Treat the Central Nervous System

被引：48
作者：
Braccioli, Luca [1 ,2 ]
van Velthoven, Cindy [1 ]
Heijnen, Cobi J. [1 ,3 ]
机构：
[1] Univ Med Ctr Utrecht, Lab Neuroimmunol & Dev Origins Dis NIDOD, NL-3584 EA Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands
[3] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Lab Neuroimmunol Canc Related Symptoms NICRS, Inst Biosci & Technol, Houston, TX 77030 USA
来源：
MOLECULAR NEUROBIOLOGY | 2014年 / 49卷 / 01期
关键词：
Exosomes; Central nervous system; Mesenchymal stem cells; Brain damage; Drug delivery; Brain regeneration; MESENCHYMAL STEM-CELLS; SECRETORY PATHWAY; DRUG-DELIVERY; STROMAL CELLS; CEREBROSPINAL-FLUID; TERMINAL FRAGMENTS; NEURITE OUTGROWTH; NEURONAL SURVIVAL; MEDIATED TRANSFER; IMMUNE-RESPONSES;
D O I：
10.1007/s12035-013-8504-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The potential of exosomes to treat central nervous system (CNS) pathologies has been recently demonstrated. These studies make way for a complete new field that aims to exploit the natural characteristics of these vesicles, considered for a long time as side products of physiological cellular pathways. Recently, however, the biological significance of exosomes has been evaluated and exosomes can now be viewed upon as new relevant functional entities for development of novel therapeutic strategies. In this review, we aim to summarize the state-of-the-art role of exosomes in the CNS and to speculate about possible future therapeutic applications of exosomes. In particular, we will speculate about the use of these vesicles as a substitute of cell-based therapies for the treatment of brain damage and review the potential of exosomes as drug delivery vehicles for the CNS.
引用
收藏
页码：113 / 119
页数：7
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