Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases

被引：39

作者：

Chen, Xiaodong ^{[1
]}

Wang, Shijia ^{[1
]}

Cao, Wei ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci,Shanghai Ins, 320 Yueyang Rd, Shanghai 200031, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2018年 / 326卷

关键词：

Mesenchymal stem cells; neurodegenerative diseases; immunomodulation; microglia; T cells; AMYOTROPHIC-LATERAL-SCLEROSIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ADAPTIVE IMMUNE-RESPONSES; AMYLOID-BETA DEPOSITION; CENTRAL-NERVOUS-SYSTEM; MOTOR-NEURON DISEASE; VERSUS-HOST-DISEASE; BLOOD-BRAIN-BARRIER; MOUSE MODEL; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.cellimm.2017.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dysfunction of immune responses has been identified to involve in the pathogenesis of various neurodegenerative diseases. Abnormal activation of glia cells and/or infiltration of peripheral adaptive immune cells always sustains neuroinflammation and the disease progression. Obviously, the regulation of neuroinflammation has become a potential therapeutic strategy against neurodegenerative diseases. Mesenchymal stem cells (MSCs) exhibit complex interactions with various immune cells including T cells, macrophages and especially resident glia cells in the central nervous system. In response to tissue injury signals, MSCs adopt specific phenotype to suppress or promote immune responses depending on the inflammatory microenvironment they reside. Therefore, manipulation of MSCs may hold great potentials to improve MSC-based therapy on neurodegenerative diseases. Here we review MSC-mediated immunomodulation in cell therapy of neurodegenerative diseases, providing fundamental information for guiding appropriate applications of MSCs in clinical settings.

引用

页码：8 / 14

页数：7

共 109 条

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