Targeted Theranostic Nanoparticles: Receptor- Mediated Entry into Cells, pH- Induced Signal Generation and Cytosolic Delivery

被引：10
作者：
Lee, Ji Yeon [1 ,2 ]
Choi, Doo-Yeol [1 ,2 ]
Cho, Mi Young [1 ,2 ]
Park, Kyoung Eun [1 ,2 ]
Lee, Seon-Ho [1 ,2 ]
Cho, Seong Hun [1 ,2 ]
Hong, Kwan Soo [3 ]
Lim, Yong Taik [1 ,2 ]
机构：
[1] Chungnam Natl Univ, Grad Sch, Taejon 305764, South Korea
[2] Chungnam Natl Univ, Dept Analyt Sci & Technol, Taejon 305764, South Korea
[3] Korea Basic Sci Inst, Div Magnet Resonance Res, Cheongwon 363883, South Korea
来源：
SMALL | 2014年 / 10卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
fluorescence; polymeric nanoparticles; theranosis; cancer cells; hydrophobicity; CANCER; PACLITAXEL; POLYMERS; DESIGN; TISSUE;
D O I：
10.1002/smll.201302136
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption. © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
引用
收藏
页码：901 / 906
页数：6
相关论文
共 48 条
  • [1] Nanomaterials: Applications in Cancer Imaging and Therapy
    Barreto, Jose A.
    O'Malley, William
    Kubeil, Manja
    Graham, Bim
    Stephan, Holger
    Spiccia, Leone
    [J]. ADVANCED MATERIALS, 2011, 23 (12) : H18 - H40
  • [2] Baselga J, 1998, CANCER RES, V58, P2825
  • [3] Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe
    Bhushan, Kumar R.
    Misra, Preeti
    Liu, Fangbing
    Mathur, Sanjeev
    Lenkinski, Robert E.
    Frangioni, John V.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (52) : 17648 - +
  • [4] Microbial biosynthesis of polyglutamic acid biopolymer and applications in the biopharmaceutical, biomedical and food industries
    Buescher, Joerg M.
    Margaritis, Argyrios
    [J]. CRITICAL REVIEWS IN BIOTECHNOLOGY, 2007, 27 (01) : 1 - 19
  • [5] Cardoso MM, 2012, CURR MED CHEM, V19, P3103
  • [6] Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots
    Choi, Hak Soo
    Ipe, Binil Itty
    Misra, Preeti
    Lee, Jeong Heon
    Bawendi, Moungi G.
    Frangioni, John V.
    [J]. NANO LETTERS, 2009, 9 (06) : 2354 - 2359
  • [7] Quantitative Assessment of the Comparative Nanoparticle-Uptake Efficiency of a Range of Cell Lines
    dos Santos, Tiago
    Varela, Juan
    Lynch, Iseult
    Salvati, Anna
    Dawson, Kenneth A.
    [J]. SMALL, 2011, 7 (23) : 3341 - 3349
  • [8] Review of a viral peptide nanosystem for intracellular delivery
    Falanga, Annarita
    Tarallo, Rossella
    Galdiero, Emilia
    Cantisani, Marco
    Galdiero, Massimiliano
    Galdiero, Stefania
    [J]. JOURNAL OF NANOPHOTONICS, 2013, 7
  • [9] Light-controlled on-off switch of a fluorescent nanoparticle
    Furukawa, Hidemitsu
    Misu, Manami
    Ando, Kazuhiro
    Kawaguchi, Haruma
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2008, 29 (07) : 547 - 551
  • [10] Quantum dot-based protein micro- and nanoarrays for detection of prostate cancer biomarkers
    Gokarna, Anisha
    Jin, Li-Hua
    Hwang, Jun Seok
    Cho, Yong-Hoon
    Lim, Yong Taik
    Chung, Bong Hyun
    Youn, Seong Hun
    Choi, Dong Sik
    Lim, Jung Hyurk
    [J]. PROTEOMICS, 2008, 8 (09) : 1809 - 1818
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