Total synthesis of ecteinascidin 743

被引：281

作者：

Endo, A ^{[1
]}

Yanagisawa, A ^{[1
]}

Abe, M ^{[1
]}

Tohma, S ^{[1
]}

Kan, T ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, CREST, Japan Sci & Technol Cooperat,JST,Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 23期

关键词：

D O I：

10.1021/ja026216d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation. Copyright © 2002 American Chemical Society.

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页码：6552 / 6554

页数：3

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