A methyl glucuronate prodrug of phosphorodiamidic mustard

被引：10
作者：
Ghosh, AK
Farquhar, D
机构：
[1] Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期
关键词：
D O I：
10.1016/S0040-4039(97)10419-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-[Methyl(beta-D-glucopyranosyl)uronate]benzyl N,N,N',N'-tetrakis(2-chloroethyl) phosphorodiamidate, 3, was synthesized as a neutral prodrug of N,N,N',N'-tetrakis(2-chloroethyl) phosphorodiamidate mustard, 2c. In the presence of carboxylate esterase and beta-D-glucuronidase, 3 was converted to 2c and 4-hydroxybenzyl alcohol, 7. (C) 1997 Elsevier Science Ltd.
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页码：8795 / 8798
页数：4
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