Importance of TNFα and neutral lipases in human adipose tissue lipolysis

被引:110
|
作者
Langin, Dominique [1 ]
Arner, Peter
机构
[1] INSERM, U586, Unite Rech Obsesites, F-31432 Toulouse, France
[2] Univ Toulouse 3, Inst Luis Bugnard, IFR31, F-31432 Toulouse, France
[3] CHU Toulouse, Biochim Lab, Inst Federatif Biol Purpan, F-31059 Toulouse, France
[4] INSERM, Franco Czech Lab Clin Res Obes, CZ-10100 Prague, Czech Republic
[5] Karolinska Univ Hosp, Karolinska Inst, Dept Med, S-14186 Huddinge, Sweden
来源
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 08期
关键词
D O I
10.1016/j.tem.2006.08.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Catecholamines and natriuretic peptides stimulate human adipocyte lipolysis through an increase in cAMP and cGMP levels, resulting in phosphorylation and activation of hormone-sensitive lipase. A defect in hormone-sensitive lipase expression might contribute to the resistance to catecholamine-induced lipolysis observed in obesity. The respective roles and regulation of hormone-sensitive lipase and adipose triglyceride lipase in spontaneous and hormone-stimulated lipolysis remain to be determined. Tumor necrosis factor alpha stimulates triglyceride hydrolysis by multiple intracellular pathways acting on insulin signaling, G proteins and perilipins, and might contribute to enhanced plasma fatty acid levels in obesity. Characterization of the lipolytic pathways might provide novel strategies to decrease free fatty acid production and reverse insulin resistance and other obesity-related metabolic complications.
引用
收藏
页码:314 / 320
页数:7
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