Sleep spindles and human cortical nociception: a surface and intracerebral electrophysiological study

被引:15
作者
Claude, Lea [1 ]
Chouchou, Florian [1 ]
Prados, German [1 ]
Castro, Maite [1 ]
De Blay, Barbara [1 ]
Perchet, Caroline [1 ]
Garcia-Larrea, Luis [1 ]
Mazza, Stephanie [2 ]
Bastuji, Helene [1 ,3 ]
机构
[1] CNRS UMR5292, Cent Integrat Pain NeuroPain Lab, INSERM U1028, Neurosci Res Ctr, Lyon, France
[2] Univ Lumiere Lyon 2, Lab Etud Mecanismes Cognitifs EMC, Bron, France
[3] Hosp Civils Lyon, Serv Neurol Fonct & Epileptol, Unite Hypnol, Hop Neurol, F-69500 Bron, France
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2015年 / 593卷 / 22期
关键词
EVENT-RELATED POTENTIALS; EVOKED-POTENTIALS; MEDIAL PULVINAR; BRAIN ACTIVITY; K-COMPLEX; RESPONSES; PAIN; MEMORY; STIMULATION; RHYTHMS;
D O I
10.1113/JP270941
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Responsiveness to environmental stimuli declines during sleep, and sleep spindles are often considered to play a major role in inhibiting sensory inputs. In the present study, we tested the effect of spindles on behavioural, autonomic and cortical responses to pain, in two experiments assessing surface and intracerebral responses to thermo-nociceptive laser stimuli during the all-night N2 sleep stage. The percentage of arousals remained unchanged as a result of the presence of spindles. Neither cortical nociceptive responses, nor autonomic cardiovascular reactivity were depressed when elicited within a spindle. These results could be replicated in human intracerebral recordings, where sleep spindle activity in the posterior thalamus failed to depress the thalamocortical nociceptive transmission, as measured by sensory responses within the posterior insula. Hence, the assumed inhibitory effect of spindles on sensory inputs may not apply to the nociceptive system, possibly as a result of the specificity of spinothalamic pathways and the crucial role of nociceptive information for homeostasis. Intriguingly, a late scalp response commonly considered to reflect high-order stimulus processing (the P3' potential) was significantly enhanced during spindling, suggesting a possible spindle-driven facilitation, rather than attenuation, of cortical nociception.
引用
收藏
页码:4995 / 5008
页数:14
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