Apoptosis: Bcl-5-related proteins get connected

被引:74
作者
Jacobson, MD
机构
关键词
D O I
10.1016/S0960-9822(06)00136-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bcl-2 family proteins are key intracellular regulators of programmed cell death. Several recent discoveries demonstrate how these proteins interact with the molecular machinery that controls and executes the cell-death programme, and how they can themselves be regulated by extracellular survival signals.
引用
收藏
页码:R277 / R281
页数:5
相关论文
共 26 条
[1]   THE PROTOONCOGENE BCL-2 CAN SELECTIVELY RESCUE NEUROTROPHIC FACTOR-DEPENDENT NEURONS FROM APOPTOSIS [J].
ALLSOPP, TE ;
WYATT, S ;
PATERSON, HF ;
DAVIES, AM .
CELL, 1993, 73 (02) :295-307
[2]   Identification of a novel regulatory domain in Bcl-x(L) and Bcl-2 [J].
Chang, BS ;
Minn, AJ ;
Muchmore, SW ;
Fesik, SW ;
Thompson, CB .
EMBO JOURNAL, 1997, 16 (05) :968-977
[3]   Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death [J].
Chinnaiyan, AM ;
ORourke, K ;
Lane, BR ;
Dixit, VM .
SCIENCE, 1997, 275 (5303) :1122-1126
[4]   New members of the Bcl-2 family and their protein partners [J].
Farrow, SN ;
Brown, R .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (01) :45-49
[5]   Apoptosis meets signal transduction: Elimination of a BAD influence [J].
Gajewski, TF ;
Thompson, CB .
CELL, 1996, 87 (04) :589-592
[6]   Controlling cell death [J].
Golstein, P .
SCIENCE, 1997, 275 (5303) :1081-1082
[7]   C-MYC-INDUCED APOPTOSIS IN FIBROBLASTS IS INHIBITED BY SPECIFIC CYTOKINES [J].
HARRINGTON, EA ;
BENNETT, MR ;
FANIDI, A ;
EVAN, GI .
EMBO JOURNAL, 1994, 13 (14) :3286-3295
[8]   C-ELEGANS CELL-SURVIVAL GENE CED-9 ENCODES A FUNCTIONAL HOMOLOG OF THE MAMMALIAN PROTOONCOGENE BCL-2 [J].
HENGARTNER, MO ;
HORVITZ, HR .
CELL, 1994, 76 (04) :665-676
[9]   PROGRAMMED CELL-DEATH IN CAENORHABDITIS-ELEGANS [J].
HENGARTNER, MO ;
HORVITZ, HR .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (04) :581-586
[10]   CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9 [J].
James, C ;
Gschmeissner, S ;
Fraser, A ;
Evan, GI .
CURRENT BIOLOGY, 1997, 7 (04) :246-252