Thrombin in inflammatory brain diseases

被引：37
作者：
Chapman, Joab [1 ]
机构：
[1] Chaim Sheba Med Ctr, Dept Neurol, IL-52621 Tel Hashomer, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-52621 Tel Hashomer, Israel
来源：
AUTOIMMUNITY REVIEWS | 2006年 / 5卷 / 08期
关键词：
multiple sclerosis; thrombin; electrophysiology; conduction block;
D O I：
10.1016/j.autrev.2006.02.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammatory brain diseases such as multiple sclerosis (MS) include hyperactivation of the coagulation pathway which includes thrombin. In the experimental autoimmune-encephalomyelitis (EAE) model we have found significantly higher levels of thrombin inhibitors which include the very early elevation of protease nexin 1. The physiological importance of excess thrombin in neural tissue is demonstrated by recent experiments which link thrombin with conduction block in the sciatic nerve. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：528 / 531
页数：4
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