Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils

被引：57
作者：
Blink, E
Maianski, NA
Alnemri, ES
Zervos, AS
Roos, D
Kuijpers, TW
机构：
[1] CLB, Sanquin Res, NL-1066 CX Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, NL-1066 CX Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, NL-1105 AZ Amsterdam, Netherlands
[4] Thomas Jefferson Univ, Kimmel Canc Inst, Ctr Apoptosis Res, Philadelphia, PA 19107 USA
[5] Univ Cent Florida, Dept Mol Biol & Microbiol, BSC, Orlando, FL 32816 USA
来源：
CELL DEATH AND DIFFERENTIATION | 2004年 / 11卷 / 08期
关键词：
D O I：
10.1038/sj.cdd.4401409
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：937 / 939
页数：3
相关论文
共 10 条
[1]   Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2 [J].
Cilenti, L ;
Lee, Y ;
Hess, S ;
Srinivasula, S ;
Park, KM ;
Junqueira, D ;
Davis, H ;
Bonventre, JV ;
Alnemri, ES ;
Zervos, AS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11489-11494
[2]   Identification of Omi/HtrA-2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction [J].
Hegde, R ;
Srinivasula, SM ;
Zhang, ZJ ;
Wassell, R ;
Mukattash, R ;
Cilenti, L ;
DuBois, G ;
Lazebnik, Y ;
Zervos, AS ;
Fernandes-Alnemri, T ;
Alnemri, ES .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) :432-438
[3]   Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α-stimulated neutrophils [J].
Liu, CY ;
Takemasa, A ;
Liles, WC ;
Goodman, RB ;
Jonas, M ;
Rosen, H ;
Chi, E ;
Winn, RK ;
Harlan, JM ;
Chuang, PI .
BLOOD, 2003, 101 (01) :295-304
[4]   Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis [J].
Maianski, NA ;
Geissler, J ;
Srinivasula, SM ;
Alnemri, ES ;
Roos, D ;
Kuijpers, TW .
CELL DEATH AND DIFFERENTIATION, 2004, 11 (02) :143-153
[5]   Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils [J].
Maianski, NA ;
Roos, D ;
Kuijpers, TW .
BLOOD, 2003, 101 (05) :1987-1995
[6]   The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif [J].
Martins, LM ;
Iaccarino, I ;
Tenev, T ;
Gschmeissner, S ;
Totty, NF ;
Lemoine, NR ;
Savopoulos, J ;
Gray, CW ;
Creasy, CL ;
Dingwall, C ;
Downward, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) :439-444
[7]   Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2 [J].
Srinivasula, SM ;
Gupta, S ;
Datta, P ;
Zhang, ZJ ;
Hegde, R ;
Cheong, NE ;
Fernandes-Alnemri, T ;
Alnemri, ES .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (34) :31469-31472
[8]   A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death [J].
Suzuki, Y ;
Imai, Y ;
Nakayama, H ;
Takahashi, K ;
Takio, K ;
Takahashi, R .
MOLECULAR CELL, 2001, 8 (03) :613-621
[9]   HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins [J].
Verhagen, AM ;
Silke, J ;
Ekert, PG ;
Pakusch, M ;
Kaufmann, H ;
Connolly, LM ;
Day, CL ;
Tikoo, A ;
Burke, R ;
Wrobel, C ;
Moritz, RL ;
Simpson, RJ ;
Vaux, DL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) :445-454
[10]   Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis [J].
Yang, QH ;
Church-Hajduk, R ;
Ren, JY ;
Newton, ML ;
Du, CY .
GENES & DEVELOPMENT, 2003, 17 (12) :1487-1496
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