4-functionally substituted 3-heterylpyrazoles: VIII. 3-aryl(heteryl)-4-hydroxyl(chloro)methylpyrazoles

被引：10

作者：

Bratenko, MK

Chornous, VA

Vovk, MV

机构：

[1] Bukovina State Med Acad, UA-58000 Chernovtsy, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-252143 Kiev, Ukraine

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 38卷 / 03期

关键词：

Aldehyde; Chloro; Pyrazole; Mild Condition; Phosphonium;

D O I：

10.1023/A:1016346528487

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Aryl(heteryl)pyrazole-4-carbaldehydes were reduced with sodium tetrahydridoborate under mild conditions to give 3-aryl(heteryl)-4-hydroxymethylpyrazoles which were converted into the corresponding 4-chloromethyl derivatives by treatment with thionyl chloride. The subsequent reaction with triphenylphosphine led to formation of triphenyl(4-pyrazolylmethyl)phosphonium chlorides, and Wittig reaction of the latter with aromatic or heteroaromatic aldehydes yielded 4-[2-aryl(heteryl)ethenyl]pyrazoles.

引用

页码：411 / 414

页数：4