Developing a vaccine for Type 1 diabetes through targeting enteroviral infections

被引：19
作者：
Hyoty, Heikki [1 ,2 ]
Knip, Mikael [3 ,4 ,5 ,6 ,7 ]
机构：
[1] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland
[2] Pirkanmaa Hosp Dist, Fimlab Labs, Tampere, Finland
[3] Univ Helsinki, Childrens Hosp, Helsinki, Finland
[4] Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland
[5] Univ Helsinki, Diabet & Obes Res Program, Helsinki, Finland
[6] Folkhalsan Res Ctr, Helsinki, Finland
[7] Tampere Univ Hosp, Dept Pediat, Tampere, Finland
来源：
EXPERT REVIEW OF VACCINES | 2014年 / 13卷 / 08期
基金：
芬兰科学院;
关键词：
antiviral drugs; enterovirus; Type; 1; diabetes; vaccine; DIFFERENT EUROPEAN POPULATIONS; HUMORAL IMMUNE-RESPONSE; CAPSID PROTEIN VP1; COXSACKIEVIRUS B3; ISLET-CELL; VIRUS-INFECTION; BETA-CELLS; RISK; AUTOIMMUNITY; MICE;
D O I：
10.1586/14760584.2014.933078
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type 1 diabetes (T1D) is a chronic disease caused by the destruction of insulin producing -cells in the pancreas. Studies carried out during the past decades have implied that enteroviruses could be an important causative agent. These findings have generated efforts aiming at developing vaccines against these viruses and testing their efficacy against T1D in clinical trials. Extensive work has been carried out to define the serotype of enteroviruses which are linked to T1D and which should be included in the vaccine, and experimental vaccines have been shown to be effective and safe in mouse models. Large-scale studies are currently in progress to increase the confidence in the scientific concept of the enterovirus-diabetes association, paralleling the efforts aimed at starting the clinical development of the vaccine. This review summarizes recent progress in this field and the scenarios regarding this development process.
引用
收藏
页码：989 / 999
页数：11
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