Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children

被引：6

作者：

Pastucha, Dalibor ^{[1
]}

Filipcikova, Radka ^{[2
]}

Horakova, Dagmar ^{[3
]}

Azeem, Katerina ^{[3
]}

Malincikova, Jana ^{[1
]}

Kocvrlich, Marek ^{[1
]}

机构：

[1] Palacky Univ, Fac Med & Dent, Dept Sports & Exercise Med, Olomouc 77520, Czech Republic

[2] Palacky Univ, Fac Med & Dent, Dept Anat, Olomouc 77520, Czech Republic

[3] Palacky Univ, Fac Med & Dent, Dept Prevent Med, Olomouc 77520, Czech Republic

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2014年 / 27卷 / 7-8期

关键词：

adolescents; children; HOMA-IR; metabolic syndrome; obesity; 3RD NATIONAL-HEALTH; HOMA-IR; CARDIOVASCULAR RISK; ADOLESCENTS; PREVALENCE; CHILDHOOD; CONSENSUS; ASSOCIATION; OVERWEIGHT;

D O I：

10.1515/jpem-2013-0310

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The study aimed to determine the incidence of metabolic syndrome (MS) in a group of Czech obese children, to evaluate the incidence of insulin resistance according to HOMA-IR in this group, and to consider the diagnostic value of HOMA-IR in early MS detection in obese children using the logistic regression models for analyzing the relations between HOMA IR and MS. Subjects and Methods: Anthropometric and laboratory examinations were performed in a group of 274 obese children aged 10-17 years. Results: MS was established in 102 subjects (37%). The presence of insulin resistance according to HOMA-IR >3.16 was ascertained in 53% of the subjects. HOMA-IR limit was exceeded by 70% in the MS (+) group and by 43% in children in the MS (-) (p<0.0001) category. Conclusion: The relatively high incidence of insulin resistance in obese children without MS questions the prevailing diagnostic criteria of, perhaps, falsely excluding some cases of, MS.

引用

页码：651 / 656

页数：6