Consensus statement on the clinical management of human immunodeficiency virus-associated neurocognitive disorders

被引：2

作者：

Podzamczer Palter, Daniel ^{[1
]}

Munoz-Moreno, Jose A. ^{[2
]}

Alcolea Rodriguez, Daniel ^{[3
]}

Alonso Villaverde, Carlos ^{[4
]}

Antela Lopez, Antonio ^{[5
]}

Blanch Andreu, Jordi ^{[6
]}

Casado Osorio, Jose Luis ^{[7
]}

Galindo Puerto, M. Jose ^{[8
]}

Garolera i Freixa, Maite ^{[9
]}

Locutura Ruperez, Jaime ^{[10
]}

Lleo Bisa, Albert ^{[3
]}

Prats Paris, Anna ^{[2
,11
]}

Perez-Valero, Ignacio ^{[12
]}

Portilla Sogorb, Joaquin ^{[13
]}

Rovira Canellas, Alex ^{[14
]}

Tellez Molina, M. Jesus ^{[15
]}

Manuel Tiraboschi, Juan ^{[1
]}

Vergara Moragues, Esperanza ^{[16
]}

Arribas Lopez, Jose Ramon ^{[17
]}

Goenaga Sanchez, Miguel Angel ^{[18
]}

Lozano de Leon-Naranjo, Fernando ^{[19
]}

Martinez Chamorro, Esteban ^{[6
]}

Polo Rodriguez, Rosa ^{[20
]}

机构：

[1] Hosp Univ Bellvitge, Lhospitalet De Llobregat, Spain

[2] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

[3] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[4] Hosp St Pau & Santa Tecla, Tarragona, Spain

[5] Hosp Clin Univ, La Coruna, Spain

[6] Hosp Clin Barcelona, Barcelona, Spain

[7] Hosp Ramon & Cajal, E-28034 Madrid, Spain

[8] Hosp Clin Valencia, Valencia, Spain

[9] Consorci Sanitari Terrassa, Barcelona, Spain

[10] Hosp Gen Yague, Burgos, Spain

[11] Ctr Med Teknon, Barcelona, Spain

[12] Hosp Univ La Paz IDIPAZ, Madrid, Spain

[13] Hosp Gen Univ Alicante, Alicante, Spain

[14] Hosp Vail Hebron, Barcelona, Spain

[15] Hosp Clin San Carlos, Madrid, Spain

[16] Hosp Univ Puerto Real, Cadiz, Spain

[17] Hosp Univ La Paz, Madrid, Spain

[18] Hosp Univ Donostia, Donostia San Sebastian, Spain

[19] Hosp Univ Nuestra Seniora de Valme, Seville, Spain

[20] Minist Sanidad, Serv Soci Igualdad, Secretaria Plan Nacl & Sida, Madrid, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2014年 / 32卷 / 01期

关键词：

Human immunodeficiency virus; Neurocognitive disorders; Antiretroviral treatment; HIV-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; COMBINATION THERAPY; CD4; NADIR; IMPAIRMENT; ERA; COHORT; BRAIN; CNS; PREDICTOR;

D O I：

10.1016/j.eimc.2013.03.005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: To develop a consensus document containing clinical recommendations for the management of human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND). Methods: We assembled a panel of experts appointed by GeSIDA and the Secretariat of the National AIDS Plan (PNS), including internal medicine physicians with expertise in the field of HIV, neuropsychologists, neurologists and neuroradiologists. Scientific information was reviewed to October 2012 in publications and conference papers. In support of the recommendations using two levels of evidence: the strength of the recommendation in the opinion of the experts (A, B, C) and the level of empirical evidence (I, II III), two levels based on the criteria of the Infectious Disease Society of America, already used in previous documents GeSIDA/SPNS. Results: Multiple recommendations for the clinical management of these disorders are provided, including two graphics algorithms, considering both the diagnostic and possible therapeutic strategies. Conclusions: Neurocognitive disorders associated with HIV infection is currently highly prevalent, are associated with a decreased quality of life and daily activities, and given the possibility of occurrence of an increase in the coming years, there is a need to adequately manage these disorders, from a diagnostic as well as therapeutic point of view, and always from a multidisciplinary perspective. (C) 2013 Elsevier Espana, S.L. All rights reserved.

引用

页码：37 / 47

页数：11

共 36 条

[11] HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy CHARTER Study [J].

Heaton, R. K. ;

Clifford, D. B. ;

Franklin, D. R. ;

Woods, S. P. ;

Ake, C. ;

Vaida, F. ;

Ellis, R. J. ;

Letendre, S. L. ;

Marcotte, T. D. ;

Atkinson, J. H. ;

Rivera-Mindt, M. ;

Vigil, O. R. ;

Taylor, M. J. ;

Collier, A. C. ;

Marra, C. M. ;

Gelman, B. B. ;

McArthur, J. C. ;

Morgello, S. ;

Simpson, D. M. ;

McCutchan, J. A. ;

Abramson, I. ;

Gamst, A. ;

Fennema-Notestine, C. ;

Jernigan, T. L. ;

Wong, J. ;

Grant, I. .

NEUROLOGY, 2010, 75 (23) :2087-2096

[12]

JANSSEN RS, 1991, NEUROLOGY, V41, P778

[13] Principles of experience-dependent neural plasticity: Implications for rehabilitation after brain damage [J].

Kleim, Jeffrey A. ;

Jones, Theresa A. .

JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 2008, 51 (01) :S225-S239

[14] Incidence and Impact on Mortality of Severe Neurocognitive Disorders in Persons With and Without HIV Infection: A Danish Nationwide Cohort Study [J].

Lescure, Francois-Xavier ;

Omland, Lars Haukali ;

Engsig, Frederik Neess ;

Roed, Casper ;

Gerstoft, Jan ;

Pialoux, Gilles ;

Kronborg, Gitte ;

Larsen, Carsten Schade ;

Obel, Niels .

CLINICAL INFECTIOUS DISEASES, 2011, 52 (02) :235-243

[15]

Letendre S, 2007, CROI

[16]

Letendre S, 2010, 17 C RETR OPP INF 16

[17] Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system [J].

Letendre, Scott ;

Marquie-Beck, Jennifer ;

Capparelli, Edmund ;

Best, Brookie ;

Clifford, David ;

Collier, Ann C. ;

Gelman, Benjamin B. ;

McArthur, Justin C. ;

McCutchan, J. Allen ;

Morgello, Susan ;

Simpson, David ;

Grant, Igor ;

Ellis, Ronald J. .

ARCHIVES OF NEUROLOGY, 2008, 65 (01) :65-70

[18]

Letendre Scott, 2011, Top Antivir Med, V19, P137

[19] EVALUATION OF 2 NEW NEUROPSYCHOLOGICAL TESTS DESIGNED TO MINIMIZE CULTURAL-BIAS IN THE ASSESSMENT OF HIV-1 SEROPOSITIVE PERSONS - A WHO STUDY [J].

MAJ, M ;

DELIA, L ;

SATZ, P ;

JANSSEN, R ;

ZAUDIG, M ;

UCHIYAMA, C ;

STARACE, F ;

GALDERISI, S ;

CHERVINSKY, A .

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 1993, 8 (02) :123-135

[20] Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion [J].

Marcotte, TD ;

Deutsch, R ;

McCutchan, JA ;

Moore, DJ ;

Letendre, S ;

Ellis, RJ ;

Wallace, MR ;

Heaton, RK ;

Grant, I .

ARCHIVES OF NEUROLOGY, 2003, 60 (10) :1406-1412

← 1 2 3 4 →