Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

被引：44

作者：

Talmi, Yoav P. ^{[1
,2
]}

Takes, Robert P. ^{[3
]}

Alon, Eran E. ^{[1
,2
]}

Nixon, Iain J. ^{[4
]}

Lopez, Fernando ^{[5
,6
,7
]}

de Bree, Remco ^{[8
]}

Rodrigo, Juan P. ^{[5
,6
,7
]}

Shaha, Ashok R. ^{[9
]}

Halmos, Gyorgy B. ^{[10
]}

Rinaldo, Alessandra ^{[11
]}

Ferlito, Alfio

机构：

[1] Chaim Sheba Med Ctr, Dept Otolaryngol Head & Neck Surg, Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[3] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 9101, NL-6500 HB Nijmegen, Netherlands

[4] NHS Lothian, Ear Nose & Throat Dept, Lauriston Bldg,Lauriston Pl, Edinburgh, Midlothian, Scotland

[5] Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo, Spain

[6] Univ Oviedo, Inst Univ Oncol Principado Asturias, Oviedo, Spain

[7] Ctr Invest Biomed Red Canc CIBERONC, Head & Neck Oncol Unit, Madrid, Spain

[8] Univ Med Ctr Utrecht, Ctr Canc, Dept Head & Neck Surg Oncol, Utrecht, Netherlands

[9] Mem Sloan Kettering Canc Ctr, Head & Neck Serv, 1275 York Ave, New York, NY 10021 USA

[10] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, Groningen, Netherlands

[11] Univ Udine, Sch Med, Udine, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2018年 / 40卷 / 05期

关键词：

head and neck squamous cell carcinoma; lymph node metastasis; lymph node ratio; neck dissection; prognosis; ORAL-CAVITY CANCER; AMERICAN JOINT COMMITTEE; SURVIVAL; PREDICTOR; DENSITY; METASTASES; NUMBER; VALIDATION; RECURRENCE; SUPERIOR;

D O I：

10.1002/hed.25080

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC). Methods: A PubMed internet search was performed and articles meeting selection criteria were reviewed. Results: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09. Conclusion: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

引用

页码：1082 / 1090

页数：9

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