Genetic priming of a proinflammatory profile predicts low IQ in octogenarians

被引：26
作者：
Krabbe, K. S. [1 ,2 ]
Mortensen, E. L. [3 ,4 ]
Avlund, K. [3 ,4 ]
Pilegaard, H. [5 ]
Christiansen, L. [6 ]
Pedersen, A. N. [7 ]
Schroll, M. [4 ]
Jorgensen, T. [4 ]
Pedersen, B. K. [2 ]
Bruunsgaard, H. [2 ]
机构：
[1] Univ Copenhagen, Ctr Inflammat & Metab, Sect 7641, Rigshosp,CMRC,Fac Hlt Sci, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Ctr Inflammat & Metab, Dept Infect Dis, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen, Inst Publ Hlth, DK-2100 Copenhagen, Denmark
[4] Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
[5] Univ Copenhagen, Inst Mol Biol, DK-2100 Copenhagen, Denmark
[6] Univ So Denmark, Dept Epidemiol, Inst Publ Hlth, Odense, Denmark
[7] Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark
来源：
NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 05期
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
Intelligence; Brain; Aging; Cognitive aging; Inflammation; Single nucleotide polymorphisms; Cytokine; Interleukin; TNF-alpha; sTNFR; IL-6; IL-18; IL-10; NECROSIS-FACTOR-ALPHA; PROMOTER REGION POLYMORPHISMS; ALZHEIMER-DISEASE; INFLAMMATORY PROTEINS; COGNITIVE IMPAIRMENT; IL6; GENE; DEMENTIA; RISK; INTERLEUKIN-6; AGE;
D O I：
10.1016/j.neurobiolaging.2007.08.013
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The purpose of the study was to test the hypothesis that single nucleotide polymorphisms (SNPs) within interleukin (IL)-18, TNF-alpha, IL-6 and IL-10 gene promoter regions are risk factors for cognitive decline in healthy octogenarians, and to isolate the strongest inflammatory biomarkers of cognitive function in the peripheral blood. The Wechsler Adult Intelligence Scale was administered to 112 individuals at ages 80 and 85. An IL-18 haplotype was an independent risk factor of poor Performance IQ. The TNF-308GA genotype was related to individual declines in Verbal IQ, and the IL-10-592 CC genotype was related to better Verbal IQ at the age of 80. Circulating levels of TNF-alpha, sTNFRs, and IL-6 were negatively correlated with IQ at age 85 and less strongly to IQ at age 80 with activation of the TNF system as the strongest biomarker. In conclusion, SNPs related to high proinflammatory or low anti-inflammatory activity are independent risk factors of reduced cognitive function in octoganarians. Only the IL-18 haplotype was associated with inflammation in the peripheral blood and only with regard to circulating TNF-alpha. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：769 / 781
页数：13
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