Fabrication of nanodiamonds modified with hyaluronic acid and chlorin e6 for selective photothermal and photodynamic tumor therapy

被引：6

作者：

Yun, Tae Hoon ^{[1
]}

Ahn, Guk-Young ^{[1
]}

Choi, Inseong ^{[1
]}

Bae, Yeon-Ju ^{[2
]}

Hwang, Keum-Cheol ^{[2
]}

Kang, Suk-Hoon ^{[3
]}

Choi, Sung-Wook ^{[1
]}

机构：

[1] Catholic Univ Korea, Biomed & Chem Engn, Bucheon Si, Gyeonggi Do, South Korea

[2] DAT Adv Mat Co Ltd, Nano Oil Chem Div, Dangjin Si, Chungcheongnam, South Korea

[3] Korea Atom Energy Res Inst, Nucl Mat Div, Daejeon, South Korea

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2020年 / 31卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

Chlorin e6; hyaluronic acid; nanodiamond; photodynamic therapy; photothermal therapy; CELLULAR UPTAKE; GRAPHENE OXIDE; DRUG-DELIVERY; NANOPARTICLES; NANOMATERIALS; DOXORUBICIN; CHARGE; CELLS;

D O I：

10.1002/pat.5022

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Nanodiamond (ND)-based nanoparticles with hyaluronic acid (HA) and chlorin e6 (Ce6) were fabricated for potential photodynamic and photothermal tumor therapy. The ND nanoparticles conjugated with HA and Ce6 (Ce6-ND@HA) had a suitable size range about 130 nm and high zeta-potential about -35 mV. The conjugation was confirmed by UV-vis spectroscopy and the conjugation efficiency of Ce6 in these ND nanoparticles was quantified by fluorescence emission spectrum. HeLa and NIH/3T3 cell lines were used as model cells in order to evaluate the performance of ND, ND nanoparticles with HA (ND@HA), and Ce6-ND@HA. The ND@HA and Ce6-ND@HA nanoparticles had a selective uptake for HeLa cells due to the presence of HA. In addition, Ce6-ND@HA nanoparticles had a high cell ablation effect for HeLa cells due to the temperature increase caused by ND and singlet oxygen generation caused by Ce6. These results suggest that Ce6-ND@HA particles might have potential for targeted anti-tumor treatment.

引用

页码：2990 / 2998

页数：9

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