α-Tocopherol succinate improves encapsulation and anticancer activity of doxorubicin loaded in solid lipid nanoparticles

被引：54
作者：
Oliveira, Mariana S. [1 ]
Mussi, Samuel V. [1 ]
Gomes, Dawidson A. [2 ]
Yoshida, Maria Irene [3 ]
Frezard, Frederic [4 ]
Carregal, Virginia M. [4 ]
Ferreira, Lucas A. M. [1 ]
机构：
[1] Univ Fed Minas Gerais, Dept Phamaceut, Fac Pharm, Av Antonio Carlos,6627,Campus Pampulha, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Inst Exact Sci, Dept Chem, Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, Av Antonio Carlos,6627,Campus Pampulha, BR-31270901 Belo Horizonte, MG, Brazil
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2016年 / 140卷
关键词：
Solid lipid nanoparticle; Doxorubicin; alpha-Tocopherol succinate; Cancer; Cytotoxicity; METASTATIC BREAST-CANCER; VITAMIN-E; IN-VITRO; DRUG-RESISTANCE; MULTIDRUG-RESISTANCE; INDUCED APOPTOSIS; DELIVERY; THERAPY; RELEASE; CELLS;
D O I：
10.1016/j.colsurfb.2015.12.019
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
This work aimed to develop solid lipid nanoparticles (SLN) co-loaded with doxorubicin and alpha-tocopheryl succinate (TS), a succinic acid ester of alpha-tocopherol that exhibits anticancer actions, evaluating the influence of TS on drug encapsulation efficiency. The SLN were characterized for size, zeta potential, entrapment efficiency (EE), and drug release. Studies of in vitro anticancer activity were also conducted. The EE was significantly improved from 30 +/- 1% to 96 +/- 2% for SLN without and with TS at 0.4%, respectively. In contrast, a reduction in particle size from 298 +/- 1 to 79 +/- 1 nm was observed for SLN without and with TS respectively. The doxorubicin release data show that SLN provide a controlled drug release. The in vitro studies showed higher cytotoxicity for doxorubicin-TS-loaded SLN than for free doxorubicin in breast cancer cells. These findings suggest that TS-doxorubicin-loaded SLN is a promising alternative for the treatment of cancer. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：246 / 253
页数：8
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