Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes

被引：30

作者：

Choi, Sun Shim ^{[1
]}

Vallender, Eric J. ^{[1
]}

Lahn, Bruce T. ^{[1
]}

机构：

[1] Univ Chicago, Howard Hughes Med Inst, Dept Human Genet, Chicago, IL 60637 USA

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2006年 / 23卷 / 11期

关键词：

proteome evolution; 3-dimensional structure; selective constraint;

D O I：

10.1093/molbev/msl086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3-dimensional (3D) structural context of amino acid residues in a protein could significantly impact the level of selective constraint on the residues. Here, by analyzing 767 mammalian proteins, we systematically investigate how various 3D structural contexts influence selective constraint. The structural contexts we examined include solvent accessibility, secondary structure, and intramolecular residue-residue interactions. Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint.

引用

页码：2131 / 2133

页数：3

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