Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

被引：223

作者：

Schwartz, Neil ^{[1
]}

Temkin, Paul ^{[1
]}

Jurado, Sandra ^{[1
,2
]}

Lim, Byung Kook ^{[1
,3
]}

Heifets, Boris D. ^{[1
]}

Polepalli, Jai S. ^{[1
]}

Malenka, Robert C. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA

[2] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA

[3] Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA

来源：

SCIENCE | 2014年 / 345卷 / 6196期

关键词：

MEDIUM SPINY NEURONS; NEUROPATHIC PAIN; INDIRECT PATHWAYS; ADENOSINE A(2A); ARCUATE NUCLEUS; MESSENGER-RNAS; BASAL GANGLIA; ANIMAL-MODELS; GALANIN; MECHANISMS;

D O I：

10.1126/science.1253994

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several symptoms associated with chronic pain, including fatigue and depression, are characterized by reduced motivation to initiate or complete goal-directed tasks. However, it is unknown whether maladaptive modifications in neural circuits that regulate motivation occur during chronic pain. Here, we demonstrate that the decreased motivation elicited in mice by two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons. These results demonstrate a previously unknown pathological adaption in a key node of motivational neural circuitry that is required for one of the major sequela of chronic pain states and syndromes.

引用

页码：535 / 542

页数：8

共 48 条

[1] Galanin, through GalR1 but not GalR2 receptors, decreases motivation at times of high appetitive behavior [J].

Anderson, Maria E. ;

Runesson, Johan ;

Saar, Indrek ;

Langel, Ulo ;

Robinson, John K. .

BEHAVIOURAL BRAIN RESEARCH, 2013, 239 :90-93

[2] Corticostriatal functional connectivity predicts transition to chronic back pain [J].

Baliki, Marwan N. ;

Petre, Bogdan ;

Torbey, Souraya ;

Herrmann, Kristina M. ;

Huang, Lejian ;

Schnitzer, Thomas J. ;

Fields, Howard L. ;

Apkarian, A. Vania .

NATURE NEUROSCIENCE, 2012, 15 (08) :1117-+

[3] Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action [J].

Balleine, Bernard W. ;

O'Doherty, John P. .

NEUROPSYCHOPHARMACOLOGY, 2010, 35 (01) :48-69

[4] Cellular and Molecular Mechanisms of Pain [J].

Basbaum, Allan I. ;

Bautista, Diana M. ;

Scherrer, Gregory ;

Julius, David .

CELL, 2009, 139 (02) :267-284

[5] Reward-aversion circuitry in analgesia and pain: Implications for psychiatric disorders [J].

Borsook, David ;

Becerra, Lino ;

Carlezon, William A., Jr. ;

Shaw, Marnie ;

Renshaw, Perry ;

Elman, Igor ;

Levine, Jon .

EUROPEAN JOURNAL OF PAIN, 2007, 11 (01) :7-20

[6] Fatigue in neurological disorders [J].

Chaudhuri, A ;

Behan, PO .

LANCET, 2004, 363 (9413) :978-988

[7] Inflammation-induced decrease in voluntary wheel running in mice: A nonreflexive test for evaluating inflammatory pain and analgesia [J].

Cobos, Enrique J. ;

Ghasemlou, Nader ;

Araldi, Dioneia ;

Segal, David ;

Duong, Kelly ;

Woolf, Clifford J. .

PAIN, 2012, 153 (04) :876-884

[8] Concurrent activation of striatal direct and indirect pathways during action initiation [J].

Cui, Guohong ;

Jun, Sang Beom ;

Jin, Xin ;

Pham, Michael D. ;

Vogel, Steven S. ;

Lovinger, David M. ;

Costa, Rui M. .

NATURE, 2013, 494 (7436) :238-242

[9] Chronic pain and psychopathology: Research findings and theoretical considerations [J].

Dersh, J ;

Polatin, PB ;

Gatchel, RJ .

PSYCHOSOMATIC MEDICINE, 2002, 64 (05) :773-786

[10] Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin [J].

Doelen, Guel ;

Darvishzadeh, Ayeh ;

Huang, Kee Wui ;

Malenka, Robert C. .

NATURE, 2013, 501 (7466) :179-+

← 1 2 3 4 5 →