TRANSFAC:: an integrated system for gene expression regulation

被引：988
作者：
Wingender, E
Chen, X
Hehl, R
Karas, H
Liebich, I
Matys, V
Meinhardt, T
Prüss, M
Reuter, I
Schacherer, F
机构：
[1] Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany
[2] Peking Univ, Coll Life Sci, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China
[3] Tech Univ Carolo Wilhelmina Braunschweig, Biozentrum, D-39100 Braunschweig, Germany
[4] BIOBASE GmbH, D-38124 Braunschweig, Germany
来源：
NUCLEIC ACIDS RESEARCH | 2000年 / 28卷 / 01期
关键词：
D O I：
10.1093/nar/28.1.316
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TRANSFAC is a database on transcription factors, their genomic binding sites and DNA-binding profiles (http://transfac.gbf.de/TRANSFAC/). Its content has been enhanced, in particular by information about training sequences used for the construction of nucleotide matrices as well as by data on plant sites and factors. Moreover, TRANSFAC has been extended by two new modules: PathoDB provides data on pathologically relevant mutations in regulatory regions and transcription factor genes, whereas S/MARt DB compiles features of scaffold/matrix attached regions (S/MARs) and the proteins binding to them. Additionally, the databases TRANSPATH, about signal transduction, and CYTOMER, about organs and cell types, have been extended and are increasingly integrated with the TRANSFAC data sources.
引用
收藏
页码：316 / 319
页数：4
相关论文
共 28 条
[1]   The Mouse Genome Database (MGD): expanding genetic and genomic resources for the laboratory mouse [J].
Blake, JA ;
Eppig, JT ;
Richardson, JE ;
Davisson, MT .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :108-111
[2]   The mouse genome database (MGD): genetic and genomic information about the laboratory mouse [J].
Blake, JA ;
Richardson, JE ;
Davisson, MT ;
Eppig, JT .
NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :95-98
[3]   The human gene mutation database [J].
Cooper, DN ;
Ball, EV ;
Krawczak, M .
NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :285-287
[4]   Hot spot in the PROP1 gene responsible for combined pituitary hormone deficiency [J].
Deladoëy, J ;
Flück, C ;
Büyükgebiz, A ;
Kuhlmann, BV ;
Eblé, A ;
Hindmarsh, PC ;
Wu, W ;
Mullis, PE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (05) :1645-1650
[5]  
Etzold T, 1996, METHOD ENZYMOL, V266, P114
[6]  
ETZOLD T, 1997, PACIFIC S BIOCOMPUT, V2, P134
[7]   Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain [J].
Fortin, AS ;
Underhill, DA ;
Gros, P .
HUMAN MOLECULAR GENETICS, 1997, 6 (11) :1781-1790
[8]   A novel method to develop highly specific models for regulatory units detects a new LTR in GenBank which contains a functional promoter [J].
Frech, K ;
DanescuMayer, J ;
Werner, T .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 270 (05) :674-687
[9]  
FUJIBUCHI W, 1998, PACIFIC S BIOCOMPUT, V3, P681
[10]   Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms [J].
Heinemeyer, T ;
Chen, X ;
Karas, H ;
Kel, AE ;
Kel, OV ;
Liebich, I ;
Meinhardt, T ;
Reuter, I ;
Schacherer, F ;
Wingender, E .
NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :318-322
123