Determination of Stability Constants of Ibandronate Complexes with Ca(II), Mg(II) and Sr(II)

被引：0

作者：

Yilmaz, Deniz Cikla ^{[1
]}

Pekin, Mursit ^{[1
]}

机构：

[1] Marmara Univ, Dept Analyt Chem, Fac Pharm, Istanbul, Turkey

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES | 2019年 / 8卷 / 02期

关键词：

Ibandronate Metal Complexes; Bisphosphonates; pKa of Ibandronate; Potentiometric Titration; METAL-COMPLEXES; BISPHOSPHONATES; ACID; ALENDRONATE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, a potentiometric titration method by Calvin-Bjerrum and Irwing-Rosotti was used to investigate binary complexes of ibandronate sodium, a nitrogen-containing bisphosphonate, with Ca(II), Mg(II) and Sr(II). Dissociation constants (pKa) of ibandronate sodium were measured and the stability constants of the complexes formed in aqueous solutions at 22 degrees C (I = 0.11 M NaClO4) were determined. The stoichiometry of ibandronate sodium/metal complexes was found as 1/1 for each metal ion.

引用

页码：111 / 117

页数：7

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