Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder

Background: Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-ad renal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD). Methods: We examined neuroendocrine function in female survivors of intimate partner violence (IPV) with lifetime (current or remitted) PTSD (n=29) and in women who were exposed to IPV but never developed PTSD (n=20). Salivary cortisol was collected as a marker of HPA axis function at 1, 4, 9, and 11 h after awakening. Platelet epinephrine and norepinephrine were assayed as markers of sympathetic-adrenal activation. Results: Women with lifetime PTSD had significantly higher cortisol. levels across the day compared to abuse-exposed participants without PTSD, after controlling for age, depression, severity, and latency of abuse. There were no significant group differences in levels of platelet catecholamines. Conclusions: Elevated cortisol levels may be a biomarker of IPV-related lifetime PTSD, reflecting tong-tasting changes associated with trauma-exposure or possibly a reflection of risk for PTSD in women. (c) 2006 Elsevier Ltd. All rights reserved.