Surface Imprinting on Spherical Macroporous Silica for Protein Recognition

被引：5

作者：

Xu, DanDan ^{[1
]}

Li, SiQi ^{[1
]}

Pan, Ting ^{[1
]}

He, JianFeng ^{[1
]}

Wu, QuanZhou ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

CHEMISTRY LETTERS | 2018年 / 47卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Protein; Surface imprinting; Macroporous microspheres; HYDROGELS;

D O I：

10.1246/cl.180050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel surface imprinting method on macroporous SiO2 microspheres with highly ordered three-dimensional interconnected structure has been developed for bovine hemoglobin (BHb) protein recognition. The selective experiment showed that the synthesized macroporous microspheres exhibited good specific recognition for template molecules. Compared with the traditional bulk imprinted polymers, the surface imprinting microspheres showed higher binding kinetic behavior, and its binding rate constant was nearly about 7 times as large as that of the bulk imprinted polymers.

引用

页码：686 / 689

页数：4

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