A Mathematical Model and Analysis of the Anti-angiogenic and Tumor Immunotherapy

被引：0

作者：

Shi, Xiulan ^{[1
]}

He, Xiongxiong ^{[2
]}

Ou, Xianhua ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Informat Engn, Zhejiang Key Lab Signal Proc, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Informat Engn, Hangzhou, Zhejiang, Peoples R China

来源：

PROCEEDINGS OF 2015 4TH INTERNATIONAL CONFERENCE ON COMPUTER SCIENCE AND NETWORK TECHNOLOGY (ICCSNT 2015) | 2015年

关键词：

cancer; angiogenesis; immune; microenvironment; immunotherapy;

D O I：

暂无

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

This paper considers a model of tumor growth and treatment with anti-angiogenesis therapy and immunotherapy. A model consisting of five ordinary differential equations to simulate the interactions between normal cells, cancer cells, endothelial cells, immune cells and anti-angiogenic agent in tumor growth is developed. This paper also studies the effect of anti-angiogenesis therapy, immunotherapy and a combination of both therapies. Through the analysis and numerical simulation of the model, it is shown that only anti-angiogenesis therapy could not completely eliminate the tumor cells; Immunotherapy can eradicate tumor cells. The results also show that the model combined with tumor anti-angiogenesis therapy can achieve better therapeutic effect. The proportion of the overall drug used has decreased by about 17.5% through numerical simulation.

引用

页码：1549 / 1553

页数：5

共 12 条

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