Role of Anti-MHC Class I Antibody in Facilitating Transplant Accommodation

被引：18

作者：

Atz, Mary E. ^{[1
]}

Reed, Elaine F. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Immunogenet Ctr, Los Angeles, CA 90095 USA

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 2008年 / 28卷 / 06期

基金：

美国国家科学基金会;

关键词：

transplantation; accommodation; MHC class I; cell survival; endothelial cell;

D O I：

10.1615/CritRevImmunol.v28.i6.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ligation of MHC class I molecules by class I antibodies on endothelial cells leads to both proliferation and survival signal transduction. This signaling pathway has been implicated in the development of acute and chronic antibody-mediated rejection. The ability of a graft to acquire resistance to immune-mediated graft injury is the basis of accommodation. The mechanisms of MHC class I-induced accommodation are unknown, but under certain circumstances following the ligation of MHC class I molecules by antibodies, the survival pathway is activated. This review explores what is currently known about accommodation and how MHC class I signaling may play a role in the process of enhancing graft survival.

引用

页码：485 / 511

页数：27

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