Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

被引：13

作者：

Gao, Wei ^{[1
]}

Li, Hai-Ying ^{[1
]}

Wang, Li-Xin ^{[1
]}

Hao, Li-Jun ^{[1
]}

Gao, Jian-Li ^{[1
]}

Zheng, Rong-Juan ^{[1
]}

Cai, Chun-Jiang ^{[2
]}

Si, Yan-Ling ^{[1
]}

机构：

[1] Tangshan Workers Hosp, Dept Gastroenterol, Tangshan 063000, Peoples R China

[2] Tangshan TCM Hosp, Dept Spleen & Stomach, Tangshan 063003, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2014年 / 7卷 / 05期

关键词：

Omeprazole; Cirrhotic portal hypertension; Gastric mucosal injury; Prostaglandins; Tumor necrosis factor-alpha; PROSTAGLANDIN E-1; P-GLYCOPROTEIN; MECHANISMS; ULCER; LIVER;

D O I：

10.1016/S1995-7645(14)60065-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats. Methods: All rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model of cirrhotic portal hypertension. The necrotic tissue of gastric mucosa ulcer focus, degree of neutrophils infiltration at the ulcer margin, portal pressure, portal venous flow, abdominal aortic pressure, abdominal aortic blood flow at front end, gastric mucosal blood flow (GMBF), glycoprotein (GP) of gastric mucosa,basal acid secretion, H+ back diffusion, gastric mucosal damage index, NO, prostaglandin E-2 (PGE(2)) and tumor necrosis factor-alpha (TNF-alpha) were determined respectively, and the pathological changes of gastric mucosa were also observed by microscope. Results: Compared with cirrhosis group and the control group, the ulcer bottom necrotic material, gastric neutrophil infiltration and UI of the treatment group were all decreased significantly (P<0.01), GMBF value, GP values, serum NO, PGE(2), TNF-alpha were all significantly increased. Conclusions: Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

引用

页码：402 / 406

页数：5

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