Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden?

被引：15
作者：
Auletta, J. J. [1 ,2 ,3 ,4 ]
Devine, S. M. [2 ,4 ,5 ,6 ]
Waller, E. K. [7 ,8 ,9 ,10 ]
机构：
[1] Nationwide Childrens Hosp, Host Def Program, Hematol Oncol Bone Marrow Transplant & Infect Dis, 700 Childrens Dr,ED546, Columbus, OH 43205 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[3] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH USA
[4] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH USA
[5] James Canc Hosp, Blood & Marrow Transplant Program, Columbus, OH USA
[6] Solove Res Inst, Columbus, OH USA
[7] Winship Canc Inst, Bone Marrow & Stem Cell Transplant Program, Atlanta, GA USA
[8] Emory Univ, Sch Med, Dept Med, Dept Pathol, Atlanta, GA USA
[9] Emory Univ, Sch Med, Dept Hematol, Atlanta, GA USA
[10] Emory Univ, Sch Med, Dept Med Oncol, Atlanta, GA USA
来源：
BONE MARROW TRANSPLANTATION | 2016年 / 51卷 / 03期
关键词：
GRAFT-VERSUS-HOST; COLONY-STIMULATING FACTOR; REGULATORY T-CELLS; ANTIGEN-PRESENTING CELLS; BONE-MARROW-TRANSPLANTATION; TOLL-LIKE RECEPTORS; FLT3; LIGAND; G-CSF; STEM-CELLS; IN-VIVO;
D O I：
10.1038/bmt.2015.301
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and have important roles in hematopoietic engraftment, GvHD and graft-versus-leukemia responses following allogeneic hematopoietic cell transplantation (HCT). In addition, pDCs mediate antiviral immunity, particularly as they are the body's primary cellular source of type I interferon. Given their pleiotropic roles, pDCs have emerged as cells that critically impact transplant outcomes, including overall survival. In this article, we will review the pre-clinical and clinical literature, supporting the crucial roles that pDCs assume as key immune effector cells during HCT.
引用
收藏
页码：333 / 343
页数：11
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