The level and prevalence of depression and anxiety among patients with different subtypes of irritable bowel syndrome: a network meta-analysis

被引：86

作者：

Hu, Zhichao ^{[1
]}

Li, Meixuan ^{[2
]}

Yao, Liang ^{[3
]}

Wang, Yinshu ^{[4
]}

Wang, Enkang ^{[4
]}

Yuan, Jianye ^{[4
]}

Wang, Fengyun ^{[5
]}

Yang, Kehu ^{[2
]}

Bian, Zhaoxiang ^{[1
]}

Zhong, Linda L. D. ^{[1
]}

机构：

[1] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong Chinese Med Clin Study Ctr, Kowloon, 7 Baptist Univ Rd, Hong Kong 999077, Peoples R China

[2] Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

[3] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON L8S 4L8, Canada

[4] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China

[5] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China

来源：

BMC GASTROENTEROLOGY | 2021年 / 21卷 / 01期

关键词：

Irritable bowel syndrome; Depression; Anxiety; Meta-analysis; QUALITY-OF-LIFE; RISK-FACTORS; IBS; SYMPTOMS; DISORDER; HEALTH; IMPACT;

D O I：

10.1186/s12876-020-01593-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundIrritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among healthy controls and patients with different subtypes of IBS. MethodsPubMed, EMBASE and the Cochrane library were searched systematically until August 17, 2020. Studies that investigated depression and/or anxiety levels or prevalence among different IBS-subtype patients measured at baseline or the same point were included. Network meta-analysis was conducted to analyze standardized mean difference (SMD) of anxiety and depression levels, and single arm meta-analysis was performed for prevalence of anxiety and depression among different IBS subtypes. ResultsEighteen studies involving 7095 participants were included. Network meta-analyses results showed healthy controls had a lower level of depression than IBS with mixed symptoms of constipation and diarrhea (IBS-M) [SMD=-1.57; 95% confidence interval (CI)-2.21, -0.92], IBS with constipation (IBS-C) (SMD=-1.53; 95% CI-2.13, -0.93) and IBS with diarrhea (IBS-D)(SMD=-1.41; 95% CI-1.97, -0.85), while no significant difference was found between IBS unclassified (IBS-U) and healthy controls (SMD=-0.58; 95% CI -2.15, 1.00). There was also no significant difference in the level of depression among different IBS subtypes patients. The results of anxiety were similar to depression. Ranking probability showed that IBS-M was associated with the highest level of depression and anxiety symptoms, followed by IBS-C/IBS-D and IBS-U. Single-arm meta-analysis showed IBS-C had the highest prevalence of depression (38%) and anxiety (40%), followed by IBS-D, IBS-M and IBS-U.ConclusionThe results indicated that IBS-M was more likely to be associated with a higher level of depression and anxiety, and the prevalence of depression and anxiety in IBS-C was highest. The psychological screening and appropriate psychotherapy are needed for patients with IBS-C, IBS-D and IBS-M instead of IBS-U.

引用

页数：18

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