Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

被引：191

作者：

Sneddon, Julie B. ^{[1
,2
,3
]}

Tang, Qizhi ^{[4
]}

Stock, Peter ^{[4
]}

Bluestone, Jeffrey A. ^{[1
,5
]}

Roy, Shuvo ^{[6
,7
]}

Desai, Tejal ^{[6
,7
]}

Hebrok, Matthias ^{[1
,3
]}

机构：

[1] Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Broad Ctr Regenerat Med & Stem Cell Res, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Parker Inst Canc Immunotherapy, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, UCSF UC Berkeley Joint PhD Program Bioengn, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

来源：

CELL STEM CELL | 2018年 / 22卷 / 06期

关键词：

PANCREATIC BETA-CELLS; REGULATORY T-CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX; CLINICAL ISLET TRANSPLANTATION; ANTI-CD3; MONOCLONAL-ANTIBODY; INSULIN-PRODUCING CELLS; RECENT-ONSET; ALLOGRAFT-REJECTION; ENDOCRINE-CELLS; DOUBLE-BLIND;

D O I：

10.1016/j.stem.2018.05.016

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation and present state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies.

引用

页码：810 / 823

页数：14

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