Microfluidics-Directed Self-Assembly of DNA-Based Nanoparticles

被引：0
作者：
Tresset, Guillaume [1 ]
Iliescu, Ciprian [2 ,3 ]
机构：
[1] Univ Paris Saclay, Univ Paris Sud, CNRS, Lab Phys Solides, Paris, France
[2] IMT Bucharest, Natl Inst Res & Dev Microtechnol, Bucharest, Romania
[3] Acad Romanian Scientists, Bucharest, Romania
来源：
INFORMACIJE MIDEM-JOURNAL OF MICROELECTRONICS ELECTRONIC COMPONENTS AND MATERIALS | 2016年 / 46卷 / 04期
关键词：
microfluidics; self-assembly; DNA; nanoparticle; nonviral gene delivery; MULTIVALENT CATIONS; DELIVERY; CHANNEL; SIZE; CELL;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The 'bottom-up' paradigm of nanofabrication mostly relies on molecular self-assembly, a process by which individual components spontaneously form ordered structures with emerging functions. Soft nanoparticles made up of therapeutic DNA condensed by cationic lipids or surfactants hold a great potential for nonviral gene delivery. Their self-assembly is driven by strong electrostatic interactions. As a consequence, nanoparticles formulated in bulk often exhibit broad size distributions not suitable for practical delivery applications. We will review the recent strategies we developed to control the self-assembly kinetics by using microfluidic devices. This combined approach may open attractive opportunities for the directed self-assembly of complex soft nanomaterials in particular for biomedical purposes.
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页码：183 / 189
页数：7
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