Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice

被引：98

作者：

Branco Ramos Nakandakari, Susana Castelo ^{[1
]}

Munoz, Vitor Rosetto ^{[2
]}

Kuga, Gabriel Keine ^{[2
]}

Gaspar, Rafael Calais ^{[2
]}

Sant'Ana, Marcella Ramos ^{[1
]}

Betim Pavan, Isadora Carolina ^{[3
]}

Salvino da Silva, Luiz Guilherme ^{[3
]}

Morelli, Ana Paula ^{[3
]}

Simabuco, Fernando Moreira ^{[3
]}

Ramos da Silva, Adelino Sanchez ^{[4
,5
]}

de Moura, Leandro Pereira ^{[2
,6
,7
]}

Ropelle, Eduardo Rochete ^{[2
,6
,7
]}

Cintra, Dennys Esper ^{[1
,7
]}

Pauli, Jose Rodrigo ^{[2
,6
,7
]}

机构：

[1] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Lab Nutr Genom,LabGeN, Limeira, SP, Brazil

[2] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Lab Mol Biol Exercise,LaBMEx, Limeira, SP, Brazil

[3] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Multidisciplinary Lab Food & Hlth,LABMAS,FCA, Limeira, SP, Brazil

[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto, SP, Brazil

[5] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Postgrad Program Phys Educ, Ribeirao Preto, SP, Brazil

[6] Univ Estadual Campinas, UNICAMP, OCRC, Campinas, SP, Brazil

[7] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Limeira, SP, Brazil

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2019年 / 79卷

基金：

巴西圣保罗研究基金会;

关键词：

beta-Amyloid; Saturated fatty acids; Inflammation; Apoptosis; Endoplasmic reticulum stress; Alzheimer's disease; INSULIN-DEGRADING ENZYME; ALZHEIMERS-DISEASE; CHOLESTEROL-METABOLISM; A-BETA; PROTEIN; OBESITY; BRAIN; MEMORY; INHIBITION; EXPRESSION;

D O I：

10.1016/j.bbi.2019.02.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The consumption of saturated fatty acids is one of the leading risk factors for Alzheimer's Disease (AD) development. Indeed, the short-term consumption of a high-fat diet (HFD) is related to increased inflammatory signals in the hippocampus; however, the potential molecular mechanisms linking it to AD pathogenesis are not fully elucidated. In our study, we investigated the effects of short-term HFD feeding (within 3, 7 and 10 days) in AD markers and neuroinflammation in the hippocampus of mice. The short period of HFD increased fasting glucose and HOMA-IR. Also, mice fed HFD increased the protein content of beta-Amyloid, pTau, TNF alpha, IL1 beta, pJNK, PTP1B, peIF2 alpha, CHOP, Caspase3, Cleaved-Caspase3 and Alzheimer-related genes (Bax, PS1, PEN2, Aph1b). At 10 days, both neuronal (N2a) and microglial (BV2) cells presented higher expression of inflammatory and apoptotic genes when stimulated with palmitate. These findings suggest that a short period of consumption of a diet rich in saturated fat is associated with activation of inflammatory, ER stress and apoptotic signals in the hippocampus of young mice.

引用

页码：284 / 293

页数：10

共 49 条

[1] An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers [J].