A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process

被引：29

作者：

Werner, Stefan ^{[1
]}

Turner, David M. ^{[1
]}

Lyon, Michael A. ^{[1
]}

Huryn, Donna M. ^{[1
]}

Wipf, Peter ^{[1
]}

机构：

[1] Univ Pittsburgh, Ctr Chem Methodol & Lib Dev, Pittsburgh, PA 15260 USA

来源：

SYNLETT | 2006年 / 14期

关键词：

Biginelli reactions; Ugi reactions; cascades; Hsp70; pyrimidinones;

D O I：

10.1055/s-2006-949648

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of the library members in a sequence of only two one-pot reactions.

引用

页码：2334 / 2338

页数：5

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