Cytotoxic alkaloids from the marine sponge Thorectandra sp.

被引：18
|
作者：
Charan, RD [1 ]
Mckee, TC [1 ]
Boyd, MR [1 ]
机构：
[1] NCI, Mol Targets Dev Program, Ctr Canc Res, Frederick, MD 21702 USA
来源：
NATURAL PRODUCT RESEARCH | 2004年 / 18卷 / 03期
关键词：
beta-carboline; Thorectandra sp; fascaplysin; 1-deoxysecofascaplysin A;
D O I：
10.1080/14786410310001622077
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Three beta-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A ( 2), and fascaplysin ( 3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 ( breast) with an IC50 of 5.9 mug/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 ( ovarian) human tumor cell lines with IC(50)s of 1.5 and 2.2 mug/mL, respectively.
引用
收藏
页码：225 / 229
页数：5
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