Is There a Role for the Incretin System in Blood Pressure Regulation?

被引：0

作者：

Rao, Akhilesh ^{[1
]}

Nistala, Ravi ^{[1
]}

机构：

[1] Univ Missouri, Sch Med, Div Nephrol, Dept Internal Med, Columbia, MO 65212 USA

来源：

CURRENT HYPERTENSION REPORTS | 2014年 / 16卷 / 03期

关键词：

Incretin; DPP4; inhibitor; Adaptive immunity; eNOS; Blood pressure; T-reg; RAAS; Oxidative stress; Cardiorenal; PPAR; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; GLUCAGON-LIKE PEPTIDE-1; VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE SYNTHASE; SPONTANEOUSLY HYPERTENSIVE-RATS; SALT-SENSITIVE RATS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; GLP-1; RECEPTOR; INSULIN-RESISTANCE;

D O I：

10.1007/s11906-013-0417-5

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Incretin-based therapies are now well established for diabetes management and are among the frontline agents for control of hyperglycemia. In addition to their antihyperglycemic effects, evidence is emerging on the role of these agents on blood pressure regulation, cardioprotective and renoprotective properties. Because of the pleiotropic nature of these affects, these agents could offer significant benefits with regards to the cardiorenal metabolic complications that are part of the diabetes and obesity epidemic in the United States and worldwide. We review the various known mechanisms or pathways by which incretin based therapy exerts its regulation of blood pressure with emphasis on novel mechanisms such as inflammation/immunomodulation and oxidative stress.

引用

页数：8

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