Paraneoplastic immune-mediated neurological effects of systemic cancers

被引：4

作者：

Sioka, Chrissa ^{[1
]}

Fotopoulos, Andreas ^{[2
]}

Kyritsis, Athanassios P. ^{[1
,3
]}

机构：

[1] Univ Ioannina, Neurosurg Res Inst, GR-45110 Ioannina, Greece

[2] Univ Hosp Ioannina, Dept Nucl Med, Ioannina, Greece

[3] Univ Ioannina, Sch Med, Dept Neurol, GR-45110 Ioannina, Greece

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2014年 / 10卷 / 05期

关键词：

FDG PET; cancer; immunotherapy; paraneoplastic neurological syndrome; EATON MYASTHENIC SYNDROME; FDG-PET; CEREBELLAR-DEGENERATION; LIMBIC ENCEPHALITIS; DIAGNOSIS; TUMOR; UTILITY; ATAXIA; 3,4-DIAMINOPYRIDINE; AUTOANTIBODIES;

D O I：

10.1586/1744666X.2014.901151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer patients may develop paraneoplastic neurological conditions associated with autoantibodies directed against neural or neuromuscular tissues. These syndromes are frequently manifested in advance of the cancer presentation by several months or years necessitating a detailed and expensive investigation to search for the presence of a malignancy. In such cases additional assistance may be obtained by the early employment of whole body 18F flurodeoxyglucose positron emission tomography as a cancer screening imaging procedure for early cancer diagnosis and potential therapy. Effective therapy of the primary cancer consists the best current therapy for a given paraneoplastic syndrome. However, other forms of immune modulation, such as plasma exchange, intravenous gamma globulin, other immune therapies and symptomatic treatment for certain PNS may have additional benefit.

引用

页码：621 / 630

页数：10

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