A conformal array of microfabricated optically-pumped first-order gradiometers for magnetoencephalography

被引:59
作者
Nardelli, N. V. [1 ]
Perry, A. R. [1 ]
Krzyzewski, S. P. [1 ]
Knappe, S. A. [1 ,2 ]
机构
[1] Univ Colorado, Boulder, CO 80309 USA
[2] FieldLine Inc, Boulder, CO 80301 USA
关键词
Magnetometer; Atomic; Laser sensors; Quantum sensors; Optical instruments; Micro-optical devices; Spin-exchange relaxation-free (SERF); Magnetoencephalography (MEG); Optically-pumped magnetometer (OPM);
D O I
10.1140/epjqt/s40507-020-00086-4
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
An array of 21 first-order gradiometers based on zero-field optically-pumped magnetometers is demonstrated for use in magnetoencephalography. Sensors are oriented radially with respect to the head and housed in a helmet with moveable holders which conform to the shape of a scalp. Our axial gradiometers have a baseline of 2 cm and reject laser and vibrational noise as well as common-mode environmental magnetic noise. The median sensitivity of the array is 15.4 fT/Hz(1/2), measured in a human-sized magnetic shield. All magnetometers are operated independently with negative feedback to maintain atoms at zero magnetic field. This yields higher signal linearity and operating range than open-loop operation and a measurement system that is less sensitive to systematic and ambient magnetic fields. All of the system electronics and lasers are compacted into one equipment rack which offers a favorable outlook for use in clinical settings.
引用
收藏
页数:11
相关论文
共 26 条
[1]   Magnetic field imaging with microfabricated optically-pumped magnetometers [J].
Alem, Orang ;
Mhaskar, Rahul ;
Jimenez-Martinez, Ricardo ;
Sheng, Dong ;
LeBlanc, John ;
Trahms, Lutz ;
Sander, Tilmann ;
Kitching, John ;
Knappe, Svenja .
OPTICS EXPRESS, 2017, 25 (07) :7849-7858
[2]   High-sensitivity atomic magnetometer unaffected by spin-exchange relaxation [J].
Allred, JC ;
Lyman, RN ;
Kornack, TW ;
Romalis, MV .
PHYSICAL REVIEW LETTERS, 2002, 89 (13) :130801-130801
[3]   Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System [J].
Borna, Amir ;
Carter, Tony R. ;
Colombo, Anthony P. ;
Jau, Yuan-Yu ;
McKay, Jim ;
Weisend, Michael ;
Taulu, Samu ;
Stephen, Julia M. ;
Schwindt, Peter D. D. .
PLOS ONE, 2020, 15 (01)
[4]   A 20-channel magnetoencephalography system based on optically pumped magnetometers [J].
Borna, Amir ;
Carter, Tony R. ;
Goldberg, Josh D. ;
Colombo, Anthony P. ;
Jau, Yuan-Yu ;
Berry, Christopher ;
Mckay, Jim ;
Stephen, Julia ;
Weisend, Michael ;
Schwindt, Peter D. D. .
PHYSICS IN MEDICINE AND BIOLOGY, 2017, 62 (23) :8909-8923
[5]   Moving magnetoencephalography towards real-world applications with a wearable system [J].
Boto, Elena ;
Holmes, Niall ;
Leggett, James ;
Roberts, Gillian ;
Shah, Vishal ;
Meyer, Sofie S. ;
Munoz, Leonardo Duque ;
Mullinger, Karen J. ;
Tierney, Tim M. ;
Bestmann, Sven ;
Barnes, Gareth R. ;
Bowtell, Richard ;
Brookes, Matthew J. .
NATURE, 2018, 555 (7698) :657-+
[6]   On the Potential of a New Generation of Magnetometers for MEG: A Beamformer Simulation Study [J].
Boto, Elena ;
Bowtell, Richard ;
Kruger, Peter ;
Fromhold, T. Mark ;
Morris, Peter G. ;
Meyer, Sofie S. ;
Barnes, Gareth R. ;
Brookes, Matthew J. .
PLOS ONE, 2016, 11 (08)
[8]   MAGNETOENCEPHALOGRAPHY - THEORY, INSTRUMENTATION, AND APPLICATIONS TO NONINVASIVE STUDIES OF THE WORKING HUMAN BRAIN [J].
HAMALAINEN, M ;
HARI, R ;
ILMONIEMI, RJ ;
KNUUTILA, J ;
LOUNASMAA, OV .
REVIEWS OF MODERN PHYSICS, 1993, 65 (02) :413-497
[9]   SPIN-EXCHANGE SHIFT AND NARROWING OF MAGNETIC-RESONANCE LINES IN OPTICALLY PUMPED ALKALI VAPORS [J].
HAPPER, W ;
TANG, H .
PHYSICAL REVIEW LETTERS, 1973, 31 (05) :273-276
[10]   Measuring MEG closer to the brain: Performance of on-scalp sensor arrays [J].
Iivanainen, Joonas ;
Stenroos, Matti ;
Parkkonen, Lauri .
NEUROIMAGE, 2017, 147 :542-553