Risks of Testosterone for Postmenopausal Women

被引：4

作者：

Pinkerton, JoAnn V. ^{[1
]}

Blackman, Isabella ^{[1
]}

Conner, Edward Alexander ^{[1
]}

Kaunitz, Andrew M. ^{[2
]}

机构：

[1] Univ Virginia Hlth Syst, Midlife Hlth Ctr, Div Midlife Hlth, Dept Obstet & Gynecol, POB 801104, Charlottesville, VA 22908 USA

[2] Univ Florida, UF Hlth Womens Specialists, Coll Med Jacksonville, Bldg 2,Suite 20,4549 Emerson St, Jacksonville, FL 32207 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2021年 / 50卷 / 01期

关键词：

Androgen; Testosterone; Risks; Safety; Menopause; Women; Hypoactive sexual desire disorder; Genitourinary syndrome of menopause; SEXUAL DESIRE DISORDER; TRANSDERMAL TESTOSTERONE; BREAST-CANCER; DOUBLE-BLIND; INTRAVAGINAL PRASTERONE; HYSTERECTOMIZED WOMEN; ANDROGEN RECEPTOR; BODY-COMPOSITION; ESTROGEN; THERAPY;

D O I：

10.1016/j.ecl.2020.10.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transdermal testosterone therapy, dosed within premenopausal physiologic testosterone ranges, used alone or with menopausal hormone therapy for postmenopausal hypoactive sexual desire disorder, has shown short-term efficacy, with few androgenic side effects. After natural or surgical menopause, meaningful improvements include an additional satisfying sexual episode per month; improvement in desire, arousal, orgasm, pleasure, and responsiveness; and a reduction in distress. Long-term data on cardiovascular, cancer, and cognitive safety are lacking. No approved testosterone preparation is available for women. Compounded testosterone creams or reduced dosing of male-approved therapies represent off-label use. Injections or pellets cause supraphysiological testosterone levels and are not recommended. © 2020 Elsevier Inc.

引用

页码：139 / 150

页数：12

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