Effect of weak (dispersion) intermolecular interactions on physical properties of organic compounds

Data on the properties of organic compounds are collected and comparative analysis of the data is performed. The dataset contains information on properties sensitive to structural variations, such as boiling point (bp), melting point (mp), and molecular packing factor (K-p), for specially selected comparative series of compounds including homologous series. These comparative series of ca. 1000 organic compounds include saturated, unsaturated, linear, branched, and cyclic hydrocarbons with only weak sites of intermolecular interaction of dispersion type. Regular trends and features of intermolecular interactions in hydrocarbons of various classes were revealed, indicating that the intensity of intermolecular interactions is the principal characteristic that defines bp, mp, and K-p of a hydrocarbon. The molecular symmetry and shape (set of conformational states) also contributes to formation of systems of intermolecular interactions. These factors affect the density and order in molecular packing of organic compounds with the dispersion type of intermolecular interactions.