Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver

被引：67

作者：

Yeang, Han Xian Aw ^{[1
]}

Piersma, Sytse J. ^{[1
]}

Lin, Yiing ^{[2
]}

Yang, Liping ^{[1
]}

Malkova, Olga N. ^{[3
]}

Miner, Cathrine ^{[3
]}

Krupnick, Alexander S. ^{[4
]}

Chapman, William C. ^{[2
]}

Yokoyama, Wayne M. ^{[1
,3
,5
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Rheumatol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Surg, Div Transplant Surg, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

JOURNAL OF IMMUNOLOGY | 2017年 / 198卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; ADAPTIVE IMMUNITY; T-BET; INNATE; EOMES;

D O I：

10.4049/jimmunol.1601818

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e(-) NK cells are tissue resident in the liver. Thus, these studies indicate that tissue-resident NK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.

引用

页码：1417 / 1422

页数：6

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