Towards a versatile synthesis of kainoids .1. Introduction of the C-3 and C-4 substituents

被引：33

作者：

Baldwin, JE ^{[1
]}

Bamford, SJ ^{[1
]}

Fryer, AM ^{[1
]}

Rudolph, MPW ^{[1
]}

Wood, ME ^{[1
]}

机构：

[1] UNIV EXETER,DEPT CHEM,EXETER EX4 4QD,DEVON,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 14期

关键词：

D O I：

10.1016/S0040-4020(97)00190-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first stages in the synthesis of acromelic acid analogues from trans-4-hydroxy-L-proline are described. An enamine alkylation was used to stereospecifically introduce the C-3 substituent, Grignard addition to a ketone or Pd(0) catalysed cross-coupling procedures adding C-4 aryl substituents for further manipulation. A number of versatile intermediates were generated. (C) 1997 Elsevier Science Ltd.

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页码：5233 / 5254

页数：22

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