T-cell regeneration: All repertoires are not created equal

被引：203
作者：
Mackall, CL
Hakim, FT
Gress, RE
机构：
[1] NCI, MED BRANCH, NIH, BETHESDA, MD 20892 USA
[2] NCI, EXPT IMMUNOL BRANCH, NIH, BETHESDA, MD 20892 USA
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 05期
关键词：
D O I：
10.1016/S0167-5699(97)81664-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The importance of the thymus for T-cell development is a central tenet of modern immunology, but thymic-independent T-cell generation has also been described. Recent human studies have shown that the balance between thymic-dependent and thymic-independent pathways of T-cell regeneration is primarily determined by age, and that thymic-independent pathways are generally inadequate for restoration of host immunocompetence.
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页码：245 / 251
页数：7
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