5-HT2C receptor activation by m-chlorophenylpiperazine detected in humans with fMRI

被引：58
作者：
Anderson, IM
Clark, L
Elliott, R
Kulkarni, B
Williams, SR
Deakin, JFW
机构：
[1] Univ Manchester, Neurosci & Psychiat Unit, Manchester M13 9PT, Lancs, England
[2] Hope Hosp, Ctr Rheumat Dis, Salford M6 8HD, Lancs, England
来源：
NEUROREPORT | 2002年 / 13卷 / 12期
基金：
英国医学研究理事会;
关键词：
m-chlorophenylpiperazine; functional MRI; Go/no-go task; pharmacoMRI; serotonin(2C) receptors;
D O I：
10.1097/00001756-200208270-00012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Functional brain imaging using selective drug probes offers the opportunity to investigate regional neuronal activation linked to receptor stimulation or inhibition. In a placebo-control led, balanced order design in eight male volunteers, the 5-HT2C agonist, m-chlorophenylpiperazine (mCPP) increased blood oxygen level dependent (BOLD) signal in the hypothalamus, caudate, pallidum, amygdala and pyriform cortex, anterior cingulate gyrus and choroid plexus (p < 0.001 uncorrected), areas with high density of 5-HT2C receptors. Activation in the hypothalamus correlated significantly with the prolactin response (p < 0.05 small volume corrected). In a subsequent Go/NoGo task, mCPP enhanced activation in right lateral orbitofrontal cortex (p < 0.05 small volume corrected). These findings suggest that pharmacoMRI is a potentially powerful tool for investigating neurotransmitter function in humans.
引用
收藏
页码：1547 / 1551
页数：5
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